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Literature DB >> 12361918

A battle for survival: immune control and immune evasion in murine gamma-herpesvirus-68 infection.

Philip G Stevenson¹, Jessica M Boname, Brigitte de Lima, Stacey Efstathiou.

Abstract

CD8(+) T cells are generally considered a key defence against herpesviruses. The murine gamma-herpesvirus-68 encodes two proteins that limit their efficacy. M3 neutralizes chemokines, while K3 downregulates MHC class I glycoproteins. The consequence of this evasion is that CD4(+) T cells are essential to the control of persistent infection.

Entities: Disease Gene Species

Mesh：

Substances：
Interferon-gamma

Year: 2002 PMID： 12361918 DOI： 10.1016/s1286-4579(02)01643-x

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

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Cited

13 in total

1. Expression in a recombinant murid herpesvirus 4 reveals the in vivo transforming potential of the K1 open reading frame of Kaposi's sarcoma-associated herpesvirus.

Authors: Jill Douglas; Bernadette Dutia; Susan Rhind; James P Stewart; Simon J Talbot
Journal: J Virol Date: 2004-08 Impact factor: 5.103

2. Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3.

Authors: Xiaoli Wang; Rose Connors; Michael R Harris; Ted H Hansen; Lonnie Lybarger
Journal: J Virol Date: 2005-04 Impact factor: 5.103

3. In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis.

Authors: Mohsan Saeed; Masaaki Shiina; Tomoko Date; Daisuke Akazawa; Noriyuki Watanabe; Asako Murayama; Tetsuro Suzuki; Haruo Watanabe; Nobuhiko Hiraga; Michio Imamura; Kazuaki Chayama; Youkyung Choi; Krzysztof Krawczynski; T Jake Liang; Takaji Wakita; Takanobu Kato
Journal: Hepatology Date: 2011-06-26 Impact factor: 17.425

10. Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection.

Authors: James R Hair; Paul A Lyons; Kenneth G C Smith; Stacey Efstathiou
Journal: J Gen Virol Date: 2007-06 Impact factor: 3.891

A battle for survival: immune control and immune evasion in murine gamma-herpesvirus-68 infection.

1. Expression in a recombinant murid herpesvirus 4 reveals the in vivo transforming potential of the K1 open reading frame of Kaposi's sarcoma-associated herpesvirus.

2. Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3.

3. In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis.

4. An MHC class I immune evasion gene of Marek׳s disease virus.

5. In vivo function of a gammaherpesvirus virion glycoprotein: influence on B-cell infection and mononucleosis.

6. Glycoprotein L disruption reveals two functional forms of the murine gammaherpesvirus 68 glycoprotein H.

7. Perturbation of lytic and latent gammaherpesvirus infection in the absence of the inhibitory receptor CEACAM1.

8. In vivo imaging of murid herpesvirus-4 infection.

9. Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component.

10. Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection.