INTRODUCTION: The aim of the present study was to investigate different methods for determining osteoarthritis-related (OA) cartilaginous changes. MATERIALS AND METHODS: Human tibial heads were investigated radiologically, macroscopically and microscopically. The height of the hyaline cartilage was measured with the aid of a computerised digital image analysis system. RESULTS: The comparison of the different evaluation systems revealed, in part, appreciable variations in severity and produced correlations of r=-0.312-0.673. In none of the methods was a linear correlation between the histomorphometrically measured decrease in cartilage height and the increasing grade of OA evident. DISCUSSION: The microscopic scores are superior, since they provide the most precise description of cartilaginous structure. The variation in cartilage height with increasing OA is not a linear process; measurement of the cartilage height alone is not a valid parameter for determining the grade of OA.
INTRODUCTION: The aim of the present study was to investigate different methods for determining osteoarthritis-related (OA) cartilaginous changes. MATERIALS AND METHODS:Human tibial heads were investigated radiologically, macroscopically and microscopically. The height of the hyaline cartilage was measured with the aid of a computerised digital image analysis system. RESULTS: The comparison of the different evaluation systems revealed, in part, appreciable variations in severity and produced correlations of r=-0.312-0.673. In none of the methods was a linear correlation between the histomorphometrically measured decrease in cartilage height and the increasing grade of OA evident. DISCUSSION: The microscopic scores are superior, since they provide the most precise description of cartilaginous structure. The variation in cartilage height with increasing OA is not a linear process; measurement of the cartilage height alone is not a valid parameter for determining the grade of OA.
Authors: J Y Reginster; R Deroisy; L C Rovati; R L Lee; E Lejeune; O Bruyere; G Giacovelli; Y Henrotin; J E Dacre; C Gossett Journal: Lancet Date: 2001-01-27 Impact factor: 79.321
Authors: H E Panula; M M Hyttinen; J P Arokoski; T K Långsjö; A Pelttari; I Kiviranta; H J Helminen Journal: Ann Rheum Dis Date: 1998-04 Impact factor: 19.103
Authors: C Pauli; R Whiteside; F L Heras; D Nesic; J Koziol; S P Grogan; J Matyas; K P H Pritzker; D D D'Lima; M K Lotz Journal: Osteoarthritis Cartilage Date: 2012-02-18 Impact factor: 6.576
Authors: Venkata P Mantripragada; Alexander Csorba; Wesley Bova; Cynthia Boehm; Nicolas S Piuzzi; Jennifer Bullen; Ronald J Midura; George F Muschler Journal: Cartilage Date: 2022 Jan-Mar Impact factor: 3.117