OBJECTIVES: To determine the validity of the histological-histochemical grading system (HHGS) for osteoarthritic (OA) articular cartilage. METHODS: Human articular cartilage was obtained from macroscopically normal (n = 13) and OA (n = 21) knee joints. Sections of central and peripheral regions of normal samples were produced. Sections of regions containing severe, moderate, and mild OA changes were produced from each OA sample. A total of 89 sections were graded by means of the HHGS (0-14) twice by three observers. RESULTS: Average scores for regions designated severe (8.64) and moderate (5.83) OA were less than the expected (10-14 and 6-9, respectively) according to the HHGS, whereas average scores for the region designated mild (5.29) OA and central and peripheral regions (2.19) of normal cartilage were higher than expected (2-5 and 0-1, respectively). The HHGS was capable of differentiating between articular cartilage from macroscopically normal and OA joints and between the region designated severe OA and other regions. However, the HHGS did not adequately differentiate between regions designated mild and moderate OA. Values for sensitivity, specificity, and efficiency for all regions varied considerably. CONCLUSION: The HHGS is valid for normal and severe OA cartilage, but does not permit distinction between mild and moderate OA changes in articular cartilage.
OBJECTIVES: To determine the validity of the histological-histochemical grading system (HHGS) for osteoarthritic (OA) articular cartilage. METHODS:Humanarticular cartilage was obtained from macroscopically normal (n = 13) and OA (n = 21) knee joints. Sections of central and peripheral regions of normal samples were produced. Sections of regions containing severe, moderate, and mild OA changes were produced from each OA sample. A total of 89 sections were graded by means of the HHGS (0-14) twice by three observers. RESULTS: Average scores for regions designated severe (8.64) and moderate (5.83) OA were less than the expected (10-14 and 6-9, respectively) according to the HHGS, whereas average scores for the region designated mild (5.29) OA and central and peripheral regions (2.19) of normal cartilage were higher than expected (2-5 and 0-1, respectively). The HHGS was capable of differentiating between articular cartilage from macroscopically normal and OA joints and between the region designated severe OA and other regions. However, the HHGS did not adequately differentiate between regions designated mild and moderate OA. Values for sensitivity, specificity, and efficiency for all regions varied considerably. CONCLUSION: The HHGS is valid for normal and severe OA cartilage, but does not permit distinction between mild and moderate OA changes in articular cartilage.
Authors: Y Okada; M Shinmei; O Tanaka; K Naka; A Kimura; I Nakanishi; M T Bayliss; K Iwata; H Nagase Journal: Lab Invest Date: 1992-06 Impact factor: 5.662
Authors: Jessica E Goetz; Mitchell C Coleman; Douglas C Fredericks; Emily Petersen; James A Martin; Todd O McKinley; Yuki Tochigi Journal: J Orthop Res Date: 2017-01-30 Impact factor: 3.494
Authors: Rajesh Kumar; Kirsten M Grønhaug; Catharina L Davies; Jon O Drogset; Magnus B Lilledahl Journal: Biomed Opt Express Date: 2015-04-27 Impact factor: 3.732
Authors: Dongrim Seol; Yuki Tochigi; Ashley M Bogner; Ino Song; Douglas C Fredericks; Gail L Kurriger; Sonja M Smith; Jessica E Goetz; Joseph A Buckwalter; James A Martin Journal: J Orthop Res Date: 2018-05-24 Impact factor: 3.494
Authors: Josephine R Coury; Ryan Nixon; Melinda Collins; John Schwartz; Nadeen O Chahine; Daniel A Grande Journal: Cartilage Date: 2018-11-28 Impact factor: 4.634
Authors: Arash Hanifi; Xiaohong Bi; Xu Yang; Beril Kavukcuoglu; Ping Chang Lin; Edward DiCarlo; Richard G Spencer; Mathias P G Bostrom; Nancy Pleshko Journal: Am J Sports Med Date: 2012-10-29 Impact factor: 6.202
Authors: Frank Echtermeyer; Jessica Bertrand; Rita Dreier; Ingmar Meinecke; Katja Neugebauer; Martin Fuerst; Yun Jong Lee; Yeong Wook Song; Christine Herzog; Gregor Theilmeier; Thomas Pap Journal: Nat Med Date: 2009-08-16 Impact factor: 53.440