Literature DB >> 15701812

A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.

Laïla Gannoun-Zaki1, Amy Jost, Jianbing Mu, Kirk W Deitsch, Thomas E Wellems.   

Abstract

Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.

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Year:  2005        PMID： 15701812      PMCID： PMC549332          DOI： 10.1128/EC.4.2.490-492.2005

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  10 in total

1.  Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intron.

Authors:  Michael S Calderwood; Laila Gannoun-Zaki; Thomas E Wellems; Kirk W Deitsch
Journal:  J Biol Chem       Date:  2003-06-27       Impact factor: 5.157

2.  The 3D7var5.2 (var COMMON) type var gene family is commonly expressed in non-placental Plasmodium falciparum malaria.

Authors:  Gerhard Winter; Qijun Chen; Kirsten Flick; Peter Kremsner; Victor Fernandez; Mats Wahlgren
Journal:  Mol Biochem Parasitol       Date:  2003-04-03       Impact factor: 1.759

3.  A study of var gene transcription in vitro using universal var gene primers.

Authors:  H M Taylor; S A Kyes; D Harris; N Kriek; C I Newbold
Journal:  Mol Biochem Parasitol       Date:  2000-01-05       Impact factor: 1.759

4.  Malaria. Cooperative silencing elements in var genes.

Authors:  K W Deitsch; M S Calderwood; T E Wellems
Journal:  Nature       Date:  2001-08-30       Impact factor: 49.962

5.  Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.

Authors:  D A Fidock; T E Wellems
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

6.  Co-ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis.

Authors:  C Ben Mamoun; I Y Gluzman; C Hott; S K MacMillan; A S Amarakone; D L Anderson; J M Carlton; J B Dame; D Chakrabarti; R K Martin; B H Brownstein; D E Goldberg
Journal:  Mol Microbiol       Date:  2001-01       Impact factor: 3.501

7.  Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes.

Authors:  D I Baruch; B L Pasloske; H B Singh; X Bi; X C Ma; M Feldman; T F Taraschi; R J Howard
Journal:  Cell       Date:  1995-07-14       Impact factor: 41.582

8.  The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes.

Authors:  X Z Su; V M Heatwole; S P Wertheimer; F Guinet; J A Herrfeldt; D S Peterson; J A Ravetch; T E Wellems
Journal:  Cell       Date:  1995-07-14       Impact factor: 41.582

9.  A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.

Authors:  Sue A Kyes; Zoe Christodoulou; Ahmed Raza; Paul Horrocks; Robert Pinches; J Alexandra Rowe; Chris I Newbold
Journal:  Mol Microbiol       Date:  2003-06       Impact factor: 3.501

10.  Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.

Authors:  J D Smith; C E Chitnis; A G Craig; D J Roberts; D E Hudson-Taylor; D S Peterson; R Pinches; C I Newbold; L H Miller
Journal:  Cell       Date:  1995-07-14       Impact factor: 41.582
  10 in total
  30 in total

1.  Characterization of the unusual bidirectional ves promoters driving VESA1 expression and associated with antigenic variation in Babesia bovis.

Authors:  Xinyi Wang; Yu-Ping Xiao; Anne Bouchut; Basima Al-Khedery; Hongbin Wang; David R Allred
Journal:  Eukaryot Cell       Date:  2012-01-27

2.  Profile of Thomas E. Wellems.

Authors:  Tinsley H Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-19       Impact factor: 11.205

3.  New construct approaches for efficient gene silencing in plants.

Authors:  Hua Yan; Robert Chretien; Jingsong Ye; Caius M Rommens
Journal:  Plant Physiol       Date:  2006-06-09       Impact factor: 8.340

4.  Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum.

Authors:  Matthias Frank; Ron Dzikowski; Daniel Costantini; Borko Amulic; Eli Berdougo; Kirk Deitsch
Journal:  J Biol Chem       Date:  2006-02-02       Impact factor: 5.157

5.  Epigenetic memory at malaria virulence genes.

Authors:  Thanat Chookajorn; Ron Dzikowski; Matthias Frank; Felomena Li; Alisha Z Jiwani; Daniel L Hartl; Kirk W Deitsch
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-05       Impact factor: 11.205

6.  Variable switching rates of malaria virulence genes are associated with chromosomal position.

Authors:  Matthias Frank; Ron Dzikowski; Borko Amulic; Kirk Deitsch
Journal:  Mol Microbiol       Date:  2007-06       Impact factor: 3.501

7.  Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.

Authors:  Ron Dzikowski; Felomena Li; Borko Amulic; Andrew Eisberg; Matthias Frank; Suchit Patel; Thomas E Wellems; Kirk W Deitsch
Journal:  EMBO Rep       Date:  2007-08-31       Impact factor: 8.807

8.  Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum.

Authors:  Christian Epp; Felomena Li; Cali A Howitt; Thanat Chookajorn; Kirk W Deitsch
Journal:  RNA       Date:  2008-11-26       Impact factor: 4.942

9.  Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum.

Authors:  Inbar Amit-Avraham; Guy Pozner; Shiri Eshar; Yair Fastman; Netanel Kolevzon; Eylon Yavin; Ron Dzikowski
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-17       Impact factor: 11.205

10.  Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.

Authors:  Christian Flueck; Richard Bartfai; Jennifer Volz; Igor Niederwieser; Adriana M Salcedo-Amaya; Blaise T F Alako; Florian Ehlgen; Stuart A Ralph; Alan F Cowman; Zbynek Bozdech; Hendrik G Stunnenberg; Till S Voss
Journal:  PLoS Pathog       Date:  2009-09-04       Impact factor: 6.823
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