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Literature DB >> 15701048

D-Amino acid oxidase: structure, catalytic mechanism, and practical application.

Abstract

D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme that plays an important role in microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous system, and aging in mammals. DAAO from yeasts Rhodotorula gracilis and Trigonopsis variabilis are used to convert cephalosporin C into 7-aminocephalosporanic acid, the precursor of other semi-synthetic cephalosporins. This review summarizes the recent data on the enzyme localization, physiological role, gene cloning and expression, and the studies on the enzyme structure, stability, catalytic mechanism, and practical applications.

Entities: Chemical Species

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Year: 2005 PMID： 15701048

Source DB: PubMed Journal: Biochemistry (Mosc) ISSN： 0006-2979 Impact factor: 2.487

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Cited

21 in total

1. D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.

Authors: Camilo Rojas; Jesse Alt; Nancy A Ator; Ajit G Thomas; Ying Wu; Niyada Hin; Krystyna Wozniak; Dana Ferraris; Rana Rais; Takashi Tsukamoto; Barbara S Slusher
Journal: Neuropsychopharmacology Date: 2015-10-16 Impact factor: 7.853

2. d-Leucine: Evaluation in an epilepsy model.

Authors: Kylie Holden; Adam L Hartman
Journal: Epilepsy Behav Date: 2017-11-07 Impact factor: 2.937

3. Trigonopsis variabilis D-amino acid oxidase: control of protein quality and opportunities for biocatalysis through production in Escherichia coli.

Authors: Iskandar Dib; Damir Stanzer; Bernd Nidetzky
Journal: Appl Environ Microbiol Date: 2006-10-20 Impact factor: 4.792

4. Single-site oxidation, cysteine 108 to cysteine sulfinic acid, in D-amino acid oxidase from Trigonopsis variabilis and its structural and functional consequences.

Authors: Anita Slavica; Iskandar Dib; Bernd Nidetzky
Journal: Appl Environ Microbiol Date: 2005-12 Impact factor: 4.792

5. X-ray structure analysis of a unique D-amino-acid oxidase from the thermophilic fungus Rasamsonia emersonii strain YA.

Authors: Yuya Shimekake; Yuki Hirato; Rikako Funabashi; Sayoko Okazaki; Masaru Goto; Takehiro Furuichi; Hideyuki Suzuki; Yoshio Kera; Shouji Takahashi
Journal: Acta Crystallogr F Struct Biol Commun Date: 2020-10-23 Impact factor: 1.056

D-Amino acid oxidase: structure, catalytic mechanism, and practical application.

1. D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.

2. d-Leucine: Evaluation in an epilepsy model.

3. Trigonopsis variabilis D-amino acid oxidase: control of protein quality and opportunities for biocatalysis through production in Escherichia coli.

4. Single-site oxidation, cysteine 108 to cysteine sulfinic acid, in D-amino acid oxidase from Trigonopsis variabilis and its structural and functional consequences.

5. X-ray structure analysis of a unique D-amino-acid oxidase from the thermophilic fungus Rasamsonia emersonii strain YA.

6. A bi-enzymatic cascade to yield pyruvate as co-substrate for L-tyrosine production.

7. Stepwise engineering of a Pichia pastoris D-amino acid oxidase whole cell catalyst.

8. The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

9. Interaction of D-amino acid oxidase with carbon nanotubes: implications in the design of biosensors.

10. A Highly Stable D-Amino Acid Oxidase of the Thermophilic Bacterium Rubrobacter xylanophilus.