BACKGROUND: Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknown, electrophysiological evidence has linked this region to error-processing abnormalities in patients with OCD. In this functional magnetic resonance imaging (fMRI) study, we sought to further localize error-processing differences within the ACC of OCD patients compared with healthy subjects. METHODS: Event-related fMRI data were collected for eight OCD patients and seven healthy subjects during the performance of a simple cognitive task designed to elicit errors but not OCD symptoms. RESULTS: Both OCD patients and healthy subjects demonstrated dorsal ACC activation during error commission. The OCD patients exhibited significantly greater error-related activation of the rostral ACC than comparison subjects. Activity in this region was positively correlated with symptom severity in the patients. CONCLUSIONS: Error-processing abnormalities within the rostral anterior cingulate occur in the absence of symptom expression in patients with OCD.
BACKGROUND:Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknown, electrophysiological evidence has linked this region to error-processing abnormalities in patients with OCD. In this functional magnetic resonance imaging (fMRI) study, we sought to further localize error-processing differences within the ACC of OCDpatients compared with healthy subjects. METHODS: Event-related fMRI data were collected for eight OCDpatients and seven healthy subjects during the performance of a simple cognitive task designed to elicit errors but not OCD symptoms. RESULTS: Both OCDpatients and healthy subjects demonstrated dorsal ACC activation during error commission. The OCDpatients exhibited significantly greater error-related activation of the rostral ACC than comparison subjects. Activity in this region was positively correlated with symptom severity in the patients. CONCLUSIONS:Error-processing abnormalities within the rostral anterior cingulate occur in the absence of symptom expression in patients with OCD.
Authors: Tara A Niendam; Angela R Laird; Kimberly L Ray; Y Monica Dean; David C Glahn; Cameron S Carter Journal: Cogn Affect Behav Neurosci Date: 2012-06 Impact factor: 3.282
Authors: Brian P Brennan; Olga Tkachenko; Zachary J Schwab; Richard J Juelich; Erin M Ryan; Alison J Athey; Harrison G Pope; Michael A Jenike; Justin T Baker; William D S Killgore; James I Hudson; J Eric Jensen; Scott L Rauch Journal: Neuropsychopharmacology Date: 2015-02-09 Impact factor: 7.853
Authors: Melisa Carrasco; Christina Hong; Jenna K Nienhuis; Shannon M Harbin; Kate D Fitzgerald; William J Gehring; Gregory L Hanna Journal: Neurosci Lett Date: 2013-02-20 Impact factor: 3.046