Literature DB >> 15686899

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

Jennifer J Turner1, Jackie P Healy, Renwick C J Dobson, Juliet A Gerrard, Craig A Hutton.   

Abstract

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The enzyme catalyses the condensation of (S)-aspartate semialdehyde (ASA) and pyruvate to form dihydrodipicolinate. Two new irreversible inhibitors of dihydrodipicolinate synthase are reported, designed to mimic the acyclic enzyme-bound condensation product of ASA and pyruvate. These compounds represent an important new lead in the design of potent inhibitors for this enzyme.

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Year:  2005        PMID： 15686899     DOI： 10.1016/j.bmcl.2004.12.043

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera.

Authors:  Sarah C Atkinson; Con Dogovski; Janet Newman; Renwick C J Dobson; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-11-25

2.  Molecular Interaction of Novel Compound 2-Methylheptyl Isonicotinate Produced by Streptomyces sp. 201 with Dihydrodipicolinate Synthase (DHDPS) Enzyme of Mycobacterium tuberculosis for its Antibacterial Activity.

Authors:  Salam Pradeep Singh; T C Bora; R L Bezbaruah
Journal:  Indian J Microbiol       Date:  2012-02-05       Impact factor: 2.461

3.  Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana.

Authors:  Michael D W Griffin; Jagan M Billakanti; Juliet A Gerrard; Renwick C J Dobson; F Grant Pearce
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-10-27

4.  The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution.

Authors:  Ali R Cala; Maria T Nadeau; Jan Abendroth; Bart L Staker; Alexandra R Reers; Anthony W Weatherhead; Renwick C J Dobson; Peter J Myler; André O Hudson
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2016-11-25       Impact factor: 1.056

5.  KiDoQ: using docking based energy scores to develop ligand based model for predicting antibacterials.

Authors:  Aarti Garg; Rupinder Tewari; Gajendra P S Raghava
Journal:  BMC Bioinformatics       Date:  2010-03-11       Impact factor: 3.169

6.  Kinetic, spectral, and structural studies of the slow-binding inhibition of the Escherichia coli dihydrodipicolinate synthase by 2, 4-oxo-pentanoic acid.

Authors:  William Karsten; Leonard M Thomas; Christian Fleming; Priscilla Seabourn; Christina Bruxvoort; Lilian Chooback
Journal:  Arch Biochem Biophys       Date:  2021-02-24       Impact factor: 4.013

7.  Virtual Screening of potential drug-like inhibitors against Lysine/DAP pathway of Mycobacterium tuberculosis.

Authors:  Aarti Garg; Rupinder Tewari; Gajendra P S Raghava
Journal:  BMC Bioinformatics       Date:  2010-01-18       Impact factor: 3.169

8.  L,L-diaminopimelate aminotransferase from Chlamydomonas reinhardtii: a target for algaecide development.

Authors:  Renwick C J Dobson; Irma Girón; André O Hudson
Journal:  PLoS One       Date:  2011-05-25       Impact factor: 3.240

9.  Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues.

Authors:  Priyanka Shrivastava; Vikas Navratna; Yumnam Silla; Rikeshwer P Dewangan; Atreyi Pramanik; Sarika Chaudhary; GeethaVani Rayasam; Anuradha Kumar; Balasubramanian Gopal; Srinivasan Ramachandran
Journal:  Sci Rep       Date:  2016-08-09       Impact factor: 4.379
  9 in total

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