Literature DB >> 1491056

Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde.

A Hashimoto1, T Nishikawa, T Oka, K Takahashi, T Hayashi.   

Abstract

The concurrent determination of free amino acid enantiomers and non-chiral amino acids in rat brain and serum was accomplished by high-performance liquid chromatography with fluorimetric detection after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde. The method revealed the presence of a large amount of free D-serine (0.22 mumol/g of tissue; D/D + L ratio = 0.25) in the brain whereas D-aspartate and D-alanine were established to be at trace levels. These results further support the presence of D-serine in adult brain tissues as demonstrated by recent work using gas chromatography.

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Year:  1992        PMID： 1491056     DOI： 10.1016/0378-4347(92)80300-f

Source DB:  PubMed          Journal:  J Chromatogr


  65 in total

1.  Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine.

Authors:  Yunlei Yang; Wooping Ge; Yiren Chen; Zhijun Zhang; Wanhua Shen; Chienping Wu; Muming Poo; Shumin Duan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-24       Impact factor: 11.205

2.  Synthesis, accumulation, and release of d-aspartate in the Aplysia californica CNS.

Authors:  Cory Scanlan; Ting Shi; Nathan G Hatcher; Stanislav S Rubakhin; Jonathan V Sweedler
Journal:  J Neurochem       Date:  2010-10-21       Impact factor: 5.372

3.  Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.

Authors:  Suyan Li; Yota Uno; Uwe Rudolph; Johanna Cobb; Jing Liu; Thea Anderson; Deborah Levy; Darrick T Balu; Joseph T Coyle
Journal:  Biochem Pharmacol       Date:  2018-01-03       Impact factor: 5.858

4.  Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

Authors:  Jesse Alt; Camilo Rojas; Krystyna Wozniak; Ying Wu; Dana Ferraris; Takashi Tsukamoto; Barbara Slusher
Journal:  Anal Biochem       Date:  2011-08-16       Impact factor: 3.365

5.  D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.

Authors:  M J Schell; R O Brady; M E Molliver; S H Snyder
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

6.  Purification of serine racemase: biosynthesis of the neuromodulator D-serine.

Authors:  H Wolosker; K N Sheth; M Takahashi; J P Mothet; R O Brady; C D Ferris; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

7.  Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons.

Authors:  Michael A Benneyworth; Yan Li; Alo C Basu; Vadim Y Bolshakov; Joseph T Coyle
Journal:  Cell Mol Neurobiol       Date:  2012-02-24       Impact factor: 5.046

8.  Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.

Authors:  Magalie Martineau; Ting Shi; Julien Puyal; Ann M Knolhoff; Jérôme Dulong; Bruno Gasnier; Jürgen Klingauf; Jonathan V Sweedler; Reinhard Jahn; Jean-Pierre Mothet
Journal:  J Neurosci       Date:  2013-02-20       Impact factor: 6.167

Review 9.  NMDA receptor regulation by D-serine: new findings and perspectives.

Authors:  Herman Wolosker
Journal:  Mol Neurobiol       Date:  2007-09-12       Impact factor: 5.590

10.  Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.

Authors:  A C Basu; G E Tsai; C-L Ma; J T Ehmsen; A K Mustafa; L Han; Z I Jiang; M A Benneyworth; M P Froimowitz; N Lange; S H Snyder; R Bergeron; J T Coyle
Journal:  Mol Psychiatry       Date:  2008-12-09       Impact factor: 15.992
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