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Literature DB >> 15672674

Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

Renê Oliveira Beleboni¹, Ruither Oliveira Gomes Carolino, Andrea Baldocchi Pizzo, Lissandra Castellan-Baldan, Joaquim Coutinho-Netto, Wagner Ferreira dos Santos, Norberto Cysne Coimbra.

Abstract

1. The GABAergic neurotransmission has been implicated in the modulation of many neural networks in forebrain, midbrain and hindbrain, as well as, in several neurological disorders. 2. The complete comprehension of GABA system neurochemical properties and the search for approaches in identifying new targets for the treatment of neural diseases related to GABAergic pathway are of the extreme relevance. 3. The present review will be focused on the pharmacology and biochemistry of the GABA metabolism, GABA receptors and transporters. In addition, the pathological and psychobiological implications related to GABAergic neurotransmission will be considered.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2004 PMID： 15672674 DOI： 10.1007/s10571-004-6913-z

Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046

207 in total

1. Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.

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Journal: J Neurochem Date: 1975-12 Impact factor: 5.372

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Review 3. Glial transporters for glutamate, glycine, and GABA: II. GABA transporters.

Authors: A Gadea; A M López-Colomé
Journal: J Neurosci Res Date: 2001-03-15 Impact factor: 4.164

4. GABAA receptor binding in the aging rat inferior colliculus.

Authors: J C Milbrandt; R L Albin; S M Turgeon; D M Caspary
Journal: Neuroscience Date: 1996-07 Impact factor: 3.590

5. Effects of opioid receptor blockade on defensive behavior elicited by electrical stimulation of the aversive substrates of the inferior colliculus in Rattus norvegicus (Rodentia, Muridae).

Authors: N C Coimbra; M Y Osaki; G C Eichenberger; J G Ciscato; C E Jucá; C R Biojone
Journal: Psychopharmacology (Berl) Date: 2000-11 Impact factor: 4.530

6. Effects of the blockade of opioid receptor on defensive reactions elicited by electrical stimulation within the deep layers of the superior colliculus and DPAG.

Authors: N C Coimbra; G C Eichenberger; R T Gorchinski; S Maisonnette
Journal: Brain Res Date: 1996-10-14 Impact factor: 3.252

7. Ethyl beta-carboline-3-carboxylate shows differential benzodiazepine receptor interaction.

Authors: M Nielsen; C Braestrup
Journal: Nature Date: 1980-08-07 Impact factor: 49.962

8. Regulation of neurotransmitter release by endogenous nitric oxide in striatal slices.

Authors: T Hanania; K M Johnson
Journal: Eur J Pharmacol Date: 1998-10-23 Impact factor: 4.432

Review 9. The GABAA receptor gene family: new opportunities for drug development.

Authors: Paul J Whiting
Journal: Curr Opin Drug Discov Devel Date: 2003-09

10. Electrogenic uptake of gamma-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes.

Authors: M P Kavanaugh; J L Arriza; R A North; S G Amara
Journal: J Biol Chem Date: 1992-11-05 Impact factor: 5.157

12 in total

1. Association of exposure to manganese and iron with striatal and thalamic GABA and other neurometabolites - Neuroimaging results from the WELDOX II study.

Authors: Swaantje Casjens; Urike Dydak; Shalmali Dharmadhikari; Anne Lotz; Martin Lehnert; Clara Quetscher; Christoph Stewig; Benjamin Glaubitz; Tobias Schmidt-Wilcke; David Edmondson; Chien-Lin Yeh; Tobias Weiss; Christoph van Thriel; Lennard Herrmann; Siegfried Muhlack; Dirk Woitalla; Michael Aschner; Thomas Brüning; Beate Pesch
Journal: Neurotoxicology Date: 2017-08-11 Impact factor: 4.294

2. GABA metabolism and its role in gamma-band oscillatory activity during auditory processing: An MRS and EEG study.

Authors: Christine Wyss; Desmond H Y Tse; Michael Kometer; Jürgen Dammers; Rita Achermann; N Jon Shah; Wolfram Kawohl; Irene Neuner
Journal: Hum Brain Mapp Date: 2017-05-08 Impact factor: 5.038

Review 3. Comparison of αβδ and αβγ GABA_A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.

Authors: Hua-Jun Feng; Stuart A Forman
Journal: Pharmacol Res Date: 2017-12-30 Impact factor: 7.658

10. Neuroprotective activity of parawixin 10, a compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae) in rats undergoing intrahippocampal NMDA microinjection.

Authors: Helene Aparecida Fachim; Marcia Renata Mortari; Leonardo Gobbo-Netto; Wagner Ferreira Dos Santos
Journal: Pharmacogn Mag Date: 2015 Jul-Sep Impact factor: 1.085

Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

1. Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.

2. Neuronal and glial gamma-aminobutyric acid+ transporters are distinct proteins.

Review 3. Glial transporters for glutamate, glycine, and GABA: II. GABA transporters.

4. GABAA receptor binding in the aging rat inferior colliculus.

5. Effects of opioid receptor blockade on defensive behavior elicited by electrical stimulation of the aversive substrates of the inferior colliculus in Rattus norvegicus (Rodentia, Muridae).

6. Effects of the blockade of opioid receptor on defensive reactions elicited by electrical stimulation within the deep layers of the superior colliculus and DPAG.

7. Ethyl beta-carboline-3-carboxylate shows differential benzodiazepine receptor interaction.

8. Regulation of neurotransmitter release by endogenous nitric oxide in striatal slices.

Review 9. The GABAA receptor gene family: new opportunities for drug development.

10. Electrogenic uptake of gamma-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes.

1. Association of exposure to manganese and iron with striatal and thalamic GABA and other neurometabolites - Neuroimaging results from the WELDOX II study.

2. GABA metabolism and its role in gamma-band oscillatory activity during auditory processing: An MRS and EEG study.

Review 3. Comparison of αβδ and αβγ GABA_A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.

4. γ-aminobutyric acid transporter-1 is involved in anxiety-like behaviors and cognitive function in knockout mice.

5. Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation.

6. Liposome-entrapped GABA modulates the expression of nNOS in NG108-15 cells.

Review 7. Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle.

Review 8. GABA(B) receptors in neuroendocrine regulation.

Review 9. Neurobiology of memory and anxiety: from genes to behavior.

10. Neuroprotective activity of parawixin 10, a compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae) in rats undergoing intrahippocampal NMDA microinjection.

Review 3. Glial transporters for glutamate, glycine, and GABA: II. GABA transporters.

Review 9. The GABAA receptor gene family: new opportunities for drug development.

Review 3. Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.

Review 7. Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle.

Review 8. GABA(B) receptors in neuroendocrine regulation.

Review 9. Neurobiology of memory and anxiety: from genes to behavior.

Review 3. Comparison of αβδ and αβγ GABA_A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.