Literature DB >> 1544482

Neuronal and glial gamma-aminobutyric acid+ transporters are distinct proteins.

N J Mabjeesh1, M Frese, T Rauen, G Jeserich, B I Kanner.   

Abstract

In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to beta-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to beta-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

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Year:  1992        PMID： 1544482     DOI： 10.1016/0014-5793(92)80109-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

Authors:  Hui-Ming Gao; Jau-Shyong Hong; Wanqin Zhang; Bin Liu
Journal:  J Neurosci       Date:  2002-02-01       Impact factor: 6.167

2.  Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.

Authors:  Melissa K McCoy; Terina N Martinez; Kelly A Ruhn; David E Szymkowski; Christine G Smith; Barry R Botterman; Keith E Tansey; Malú G Tansey
Journal:  J Neurosci       Date:  2006-09-13       Impact factor: 6.167

Review 3.  Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

Authors:  Renê Oliveira Beleboni; Ruither Oliveira Gomes Carolino; Andrea Baldocchi Pizzo; Lissandra Castellan-Baldan; Joaquim Coutinho-Netto; Wagner Ferreira dos Santos; Norberto Cysne Coimbra
Journal:  Cell Mol Neurobiol       Date:  2004-12       Impact factor: 5.046

4.  Expression of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter in the rat retina.

Authors:  N C Brecha; C Weigmann
Journal:  J Comp Neurol       Date:  1994-07-22       Impact factor: 3.215

5.  GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex.

Authors:  A Minelli; S DeBiasi; N C Brecha; L V Zuccarello; F Conti
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

Review 6.  Reconstitution of GABA, Glycine and Glutamate Transporters.

Authors:  Niels Christian Danbolt; Beatriz López-Corcuera; Yun Zhou
Journal:  Neurochem Res       Date:  2021-04-27       Impact factor: 3.996
  6 in total

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