Literature DB >> 15664855

Non-peptidic small molecule inhibitors of XIAP.

Cheol-Min Park1, Chaohong Sun, Edward T Olejniczak, Alan E Wilson, Robert P Meadows, Stephen F Betz, Steven W Elmore, Stephen W Fesik.   

Abstract

Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.

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Year:  2005        PMID： 15664855     DOI： 10.1016/j.bmcl.2004.11.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).

Authors:  Dharminder Chauhan; Paola Neri; Mugdha Velankar; Klaus Podar; Teru Hideshima; Mariateresa Fulciniti; Pierfrancesco Tassone; Noopur Raje; Constantine Mitsiades; Nicholas Mitsiades; Paul Richardson; Leigh Zawel; Mary Tran; Nikhil Munshi; Kenneth C Anderson
Journal:  Blood       Date:  2006-10-10       Impact factor: 22.113

2.  Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Authors:  Jui-Wen Huang; Ziming Zhang; Bainan Wu; Jason F Cellitti; Xiyun Zhang; Russell Dahl; Chung-Wai Shiau; Kate Welsh; Aras Emdadi; John L Stebbins; John C Reed; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

3.  Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.

Authors:  Darren Finlay; Mitchell Vamos; Marcos González-López; Robert J Ardecky; Santhi Reddy Ganji; Hongbin Yuan; Ying Su; Trina R Cooley; Curt T Hauser; Kate Welsh; John C Reed; Nicholas D P Cosford; Kristiina Vuori
Journal:  Mol Cancer Ther       Date:  2013-11-05       Impact factor: 6.261

4.  Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II Jurkat cells.

Authors:  Mary E Shawgo; Shary N Shelton; John D Robertson
Journal:  J Biol Chem       Date:  2009-09-16       Impact factor: 5.157

5.  Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.

Authors:  Fernando R Pinacho Crisóstomo; Yongmei Feng; Xuejun Zhu; Kate Welsh; Jing An; John C Reed; Ziwei Huang
Journal:  Bioorg Med Chem Lett       Date:  2009-09-17       Impact factor: 2.823

6.  Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction.

Authors:  Chao-Yie Yang; Haiying Sun; Jianyong Chen; Zaneta Nikolovska-Coleska; Shaomeng Wang
Journal:  J Am Chem Soc       Date:  2009-09-30       Impact factor: 15.419

Review 7.  NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.

Authors:  Elisa Barile; Maurizio Pellecchia
Journal:  Chem Rev       Date:  2014-04-08       Impact factor: 60.622

8.  Development of Peptidomimetics Targeting IAPs.

Authors:  Sushil K Sharma; Christopher Straub; Leigh Zawel
Journal:  Int J Pept Res Ther       Date:  2006-03-03       Impact factor: 1.931

9.  Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses.

Authors:  Vinod Nadella; Aparna Mohanty; Lalita Sharma; Sailu Yellaboina; Hans-Joachim Mollenkopf; Varadendra Balaji Mazumdar; Ramesh Palaparthi; Madhavi B Mylavarapu; Radheshyam Maurya; Sreenivasulu Kurukuti; Thomas Rudel; Hridayesh Prakash
Journal:  Front Immunol       Date:  2018-01-09       Impact factor: 7.561
  9 in total

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