Literature DB >> 19819692

Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.

Fernando R Pinacho Crisóstomo1, Yongmei Feng, Xuejun Zhu, Kate Welsh, Jing An, John C Reed, Ziwei Huang.   

Abstract

Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new compounds targeting the protein-protein interaction of XIAP/caspase9.

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Year:  2009        PMID： 19819692      PMCID： PMC3807767          DOI： 10.1016/j.bmcl.2009.09.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

Review 1.  Apoptosis-based therapies.

Authors:  John C Reed
Journal:  Nat Rev Drug Discov       Date:  2002-02       Impact factor: 84.694

2.  Structure-based design of potent, conformationally constrained Smac mimetics.

Authors:  Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; Meilan Liu; York Tomita; Hongguang Pan; Yoshiko Yoshioka; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Journal:  J Am Chem Soc       Date:  2004-12-29       Impact factor: 15.419

3.  Non-peptidic small molecule inhibitors of XIAP.

Authors:  Cheol-Min Park; Chaohong Sun; Edward T Olejniczak; Alan E Wilson; Robert P Meadows; Stephen F Betz; Steven W Elmore; Stephen W Fesik
Journal:  Bioorg Med Chem Lett       Date:  2005-02-01       Impact factor: 2.823

4.  Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Authors:  Haiying Sun; Zaneta Nikolovska-Coleska; Jianfeng Lu; Jennifer L Meagher; Chao-Yie Yang; Su Qiu; York Tomita; Yumi Ueda; Sheng Jiang; Krzysztof Krajewski; Peter P Roller; Jeanne A Stuckey; Shaomeng Wang
Journal:  J Am Chem Soc       Date:  2007-11-14       Impact factor: 15.419

5.  Mechanism of XIAP-mediated inhibition of caspase-9.

Authors:  Eric N Shiozaki; Jijie Chai; Daniel J Rigotti; Stefan J Riedl; Pingwei Li; Srinivasa M Srinivasula; Emad S Alnemri; Robert Fairman; Yigong Shi
Journal:  Mol Cell       Date:  2003-02       Impact factor: 17.970

6.  Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.

Authors:  Z Liu; C Sun; E T Olejniczak; R P Meadows; S F Betz; T Oost; J Herrmann; J C Wu; S W Fesik
Journal:  Nature       Date:  2000 Dec 21-28       Impact factor: 49.962

7.  Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Authors:  Kerry Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O Elliott; Heidi J A Wallweber; David C Okawa; John A Flygare; Domagoj Vucic; Wayne J Fairbrother; Kurt Deshayes
Journal:  ACS Chem Biol       Date:  2006-09-19       Impact factor: 5.100

Review 8.  Function-oriented synthesis, step economy, and drug design.

Authors:  Paul A Wender; Vishal A Verma; Thomas J Paxton; Thomas H Pillow
Journal:  Acc Chem Res       Date:  2007-12-27       Impact factor: 22.384

9.  Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Authors:  Thorsten K Oost; Chaohong Sun; Robert C Armstrong; Ali-Samer Al-Assaad; Stephen F Betz; Thomas L Deckwerth; Hong Ding; Steven W Elmore; Robert P Meadows; Edward T Olejniczak; Andrew Oleksijew; Tilman Oltersdorf; Saul H Rosenberg; Alexander R Shoemaker; Kevin J Tomaselli; Hua Zou; Stephen W Fesik
Journal:  J Med Chem       Date:  2004-08-26       Impact factor: 7.446

10.  Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.

Authors:  Wei Sun; Zaneta Nikolovska-Coleska; Dongguang Qin; Haiying Sun; Chao-Yie Yang; Longchuang Bai; Su Qiu; You Wang; Dawei Ma; Shaomeng Wang
Journal:  J Med Chem       Date:  2009-02-12       Impact factor: 7.446
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  1 in total

Review 1.  Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics.

Authors:  Ioanna Petta; Sam Lievens; Claude Libert; Jan Tavernier; Karolien De Bosscher
Journal:  Mol Ther       Date:  2015-12-17       Impact factor: 11.454
  1 in total

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