Literature DB >> 15652509

Recombinant viral capsids as an efficient vehicle of oligonucleotide delivery into cells.

Arik Cooper1, Yosef Shaul.   

Abstract

Delivery of oligonucleotides (ON) into cells is a technical challenge. In this study, we utilized the capsid of the hepatitis B virus (HBV) to meet this goal. A single and short open reading frame of the virus programs efficient capsid production in bacteria. We show that these capsids can encapsulate ON in vitro and then mediate their delivery into cells with extreme efficiency. This process is cell type non-specific, rendering the recombinant HBV capsid a potentially valuable vehicle for ON delivery into a wide range of cultured cells.

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Year:  2005        PMID： 15652509     DOI： 10.1016/j.bbrc.2004.12.118

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Maximization of loading and stability of ssDNA:iron oxide nanoparticle complexes formed through electrostatic interaction.

Authors:  Lorenzo Berti; Temesgen Woldeyesus; Yuanpei Li; Kit S Lam
Journal:  Langmuir       Date:  2010-11-03       Impact factor: 3.882

2.  On the origin of order in the genome organization of ssRNA viruses.

Authors:  Karim M ElSawy; Leo S D Caves; Reidun Twarock
Journal:  Biophys J       Date:  2011-08-17       Impact factor: 4.033

3.  Mutation of arginine residues to avoid non-specific cellular uptakes for hepatitis B virus core particles.

Authors:  Izzat Fahimuddin Bin Mohamed Suffian; Yuya Nishimura; Kenta Morita; Sachiko Nakamura-Tsuruta; Khuloud T Al-Jamal; Jun Ishii; Chiaki Ogino; Akihiko Kondo
Journal:  J Nanobiotechnology       Date:  2015-02-13       Impact factor: 10.435

4.  Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications.

Authors:  Arnis Strods; Velta Ose; Janis Bogans; Indulis Cielens; Gints Kalnins; Ilze Radovica; Andris Kazaks; Paul Pumpens; Regina Renhofa
Journal:  Sci Rep       Date:  2015-06-26       Impact factor: 4.379

5.  Monitoring the Disassembly of Virus-like Particles by 19F-NMR.

Authors:  Rogen L C Leung; Matthew D M Robinson; Alaa A A Ajabali; Gogulan Karunanithy; Brian Lyons; Ritu Raj; Saeed Raoufmoghaddam; Shabaz Mohammed; Timothy D W Claridge; Andrew J Baldwin; Benjamin G Davis
Journal:  J Am Chem Soc       Date:  2017-04-07       Impact factor: 15.419

6.  Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo.

Authors:  Izzat Fahimuddin Bin Mohamed Suffian; Julie Tzu-Wen Wang; Naomi O Hodgins; Rebecca Klippstein; Mitla Garcia-Maya; Paul Brown; Yuya Nishimura; Hamed Heidari; Sara Bals; Jane K Sosabowski; Chiaki Ogino; Akihiko Kondo; Khuloud T Al-Jamal
Journal:  Biomaterials       Date:  2016-12-14       Impact factor: 12.479

7.  Yield Optimisation of Hepatitis B Virus Core Particles in E. coli Expression System for Drug Delivery Applications.

Authors:  Izzat Fahimuddin Bin Mohamed Suffian; Mitla Garcia-Maya; Paul Brown; Tam Bui; Yuya Nishimura; Amir Rafiq Bin Mohammad Johari Palermo; Chiaki Ogino; Akihiko Kondo; Khuloud T Al-Jamal
Journal:  Sci Rep       Date:  2017-03-03       Impact factor: 4.379

8.  Engineering Human Epidermal Growth Receptor 2-Targeting Hepatitis B Virus Core Nanoparticles for siRNA Delivery in Vitro and in Vivo.

Authors:  Izzat F M Suffian; Julie T-W Wang; Farid N Faruqu; Julio Benitez; Yuya Nishimura; Chiaki Ogino; Akihiko Kondo; Khuloud T Al-Jamal
Journal:  ACS Appl Nano Mater       Date:  2018-06-20

Review 9.  RNA interference for antiviral therapy.

Authors:  Mali Ketzinel-Gilad; Yosef Shaul; Eithan Galun
Journal:  J Gene Med       Date:  2006-08       Impact factor: 4.565

10.  Production of the HBc Protein from Different HBV Genotypes in E. coli. Use of Reassociated HBc VLPs for Packaging of ss- and dsRNA.

Authors:  Ivars Petrovskis; Ilva Lieknina; Andris Dislers; Juris Jansons; Janis Bogans; Inara Akopjana; Jelena Zakova; Irina Sominskaya
Journal:  Microorganisms       Date:  2021-01-30
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