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Literature DB >> 15640237

Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481.

Patricia Uguen¹, Thomas Hindré, Sandrine Didelot, Christel Marty, Dominique Haras, Jean-Paul Le Pennec, Karine Vallée-Réhel, Alain Dufour.

Abstract

In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower.

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 15640237 PMCID： PMC544215 DOI： 10.1128/AEM.71.1.562-565.2005

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

25 in total

1. Nucleotide sequence of the streptococcin A-FF22 lantibiotic regulon: model for production of the lantibiotic SA-FF22 by strains of Streptococcus pyogenes.

Authors: R E McLaughlin; J J Ferretti; W L Hynes
Journal: FEMS Microbiol Lett Date: 1999-06-15 Impact factor: 2.742

Review 2. Lantibiotics: structure, biosynthesis and mode of action.

Authors: O McAuliffe; R P Ross; C Hill
Journal: FEMS Microbiol Rev Date: 2001-05 Impact factor: 16.408

3. Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM.

Authors: P Uguen; J P Le Pennec; A Dufour
Journal: J Bacteriol Date: 2000-09 Impact factor: 3.490

4. IS1675, a novel lactococcal insertion element, forms a transposon-like structure including the lacticin 481 lantibiotic operon.

Authors: A Dufour; A Rincé; P Uguen; J P Le Pennec
Journal: J Bacteriol Date: 2000-10 Impact factor: 3.490

5. Bacteriocin detection from whole bacteria by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

Authors: Thomas Hindré; Sandrine Didelot; Jean-Paul Le Pennec; Dominique Haras; Alain Dufour; Karine Vallée-Réhel
Journal: Appl Environ Microbiol Date: 2003-02 Impact factor: 4.792

Review 6. Lantibiotics produced by lactic acid bacteria: structure, function and applications.

Authors: Denis Twomey; R P Ross; Maire Ryan; Billy Meaney; C Hill
Journal: Antonie Van Leeuwenhoek Date: 2002-08 Impact factor: 2.271

7. HtrA is the unique surface housekeeping protease in Lactococcus lactis and is required for natural protein processing.

Authors: I Poquet; V Saint; E Seznec; N Simoes; A Bolotin; A Gruss
Journal: Mol Microbiol Date: 2000-03 Impact factor: 3.501

Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481.

1. Nucleotide sequence of the streptococcin A-FF22 lantibiotic regulon: model for production of the lantibiotic SA-FF22 by strains of Streptococcus pyogenes.

Review 2. Lantibiotics: structure, biosynthesis and mode of action.

3. Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM.

4. IS1675, a novel lactococcal insertion element, forms a transposon-like structure including the lacticin 481 lantibiotic operon.

5. Bacteriocin detection from whole bacteria by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

Review 6. Lantibiotics produced by lactic acid bacteria: structure, function and applications.

7. HtrA is the unique surface housekeeping protease in Lactococcus lactis and is required for natural protein processing.

8. The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.

9. The LcnC homologue cannot replace LctT in lacticin 481 export.

Review 10. Multidrug transporters and antibiotic resistance in Lactococcus lactis.

Review 1. Rings, radicals, and regeneration: the early years of a bioorganic laboratory.

2. Overproduction of wild-type and bioengineered derivatives of the lantibiotic lacticin 3147.

3. Influence of Ca(2+) ions on the activity of lantibiotics containing a mersacidin-like lipid II binding motif.

Review 4. Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.

5. Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate.

6. Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.

7. In vitro reconstitution and substrate specificity of a lantibiotic protease.

8. The importance of the leader sequence for directing lanthionine formation in lacticin 481.

9. Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin.

10. Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids.