Kun Chen1, Qin-Ting Jiang, Han-Qing He. 1. Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. ck@zju.edu.cn
Abstract
AIM: To clarify the influence of genetic polymorphisms on colorectal cancer. METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data. RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05). CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.
AIM: To clarify the influence of genetic polymorphisms on colorectal cancer. METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data. RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFRC677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05). CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.
Authors: S Z Abdel-Rahman; A S Soliman; M L Bondy; X Wu; S A El-Badawy; K G Mahgoub; S Ismail; I A Seifeldin; B Levin Journal: Cancer Lett Date: 1999-07-19 Impact factor: 8.679
Authors: K Przybyłowska; K Smolarczyk; A Kulig; H Romanowicz-Makowska; A Dziki; J Ulańska; B Pander; J Błasiak Journal: Cancer Lett Date: 2002-07-08 Impact factor: 8.679
Authors: Alexandre Loktionov; Mark A Watson; William S L Stebbings; Chris T M Speakman; Sheila A Bingham Journal: Cancer Lett Date: 2003-01-28 Impact factor: 8.679
Authors: Susan Nowell; Brian Coles; Rashmi Sinha; Stewart MacLeod; D Luke Ratnasinghe; Craig Stotts; Fred F Kadlubar; Christine B Ambrosone; Nicholas P Lang Journal: Mutat Res Date: 2002-09-30 Impact factor: 2.433
Authors: Steven J Hawken; Celia M T Greenwood; Thomas J Hudson; Rafal Kustra; John McLaughlin; Quanhe Yang; Brent W Zanke; Julian Little Journal: Hum Genet Date: 2010-05-01 Impact factor: 4.132
Authors: S D Ramsey; R S Holmes; C L McDermott; D K Blough; K L Petrin; E M Poole; C M Ulrich Journal: Colorectal Dis Date: 2012-09 Impact factor: 3.788
Authors: Mala Pande; Christopher I Amos; Daniel R Osterwisch; Jinyun Chen; Patrick M Lynch; Russell Broaddus; Marsha L Frazier Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-09 Impact factor: 4.254
Authors: I P M Tomlinson; M Dunlop; H Campbell; B Zanke; S Gallinger; T Hudson; T Koessler; P D Pharoah; I Niittymäki; I Niittymäkix; S Tuupanen; S Tuupanenx; L A Aaltonen; K Hemminki; A Lindblom; A Försti; O Sieber; L Lipton; T van Wezel; H Morreau; J T Wijnen; P Devilee; K Matsuda; Y Nakamura; S Castellví-Bel; C Ruiz-Ponte; A Castells; A Carracedo; J W C Ho; P Sham; R M W Hofstra; P Vodicka; H Brenner; J Hampe; C Schafmayer; J Tepel; S Schreiber; H Völzke; M M Lerch; C A Schmidt; S Buch; V Moreno; C M Villanueva; P Peterlongo; P Radice; M M Echeverry; A Velez; L Carvajal-Carmona; R Scott; S Penegar; P Broderick; A Tenesa; R S Houlston Journal: Br J Cancer Date: 2009-11-17 Impact factor: 7.640