AIM: The objective of the study was the investigation of anticancer activity of aconitine-containing herbal extract BC1 against two tumor strains with different metastatic potency: strongly metastatic Lewis lung carcinoma (LLC) and its weakly metastatic counterpart (LLC-R9). RESULTS: It was shown that low proliferative activity and high metastatic potential of LLC correlated with high refractoriness of this tumor to BC1 action, while significant inhibition of tumor growth and metastasis by BC1 were observed against actively proliferating and weakly metastatic LLC-R9. Maximal antitumor activity of BC1 (> 70% of inhibition of primary tumor growth) and antimetastatic action (88% of metastatic inhibition) were observed at the dose of MTD/20. High efficacy of BC1 against LLC-R9 was shown to be accompanied by 2-fold increase of apoptosis rate predominantly in diploid cells. CONCLUSIONS: The obtained results showed the ability of aconitine-containing herbal extract BC1 to inhibit growth of primary tumor and metastases of actively proliferating and weakly metastatic variant of Lewis lung carcinoma.
AIM: The objective of the study was the investigation of anticancer activity of aconitine-containing herbal extract BC1 against two tumor strains with different metastatic potency: strongly metastatic Lewis lung carcinoma (LLC) and its weakly metastatic counterpart (LLC-R9). RESULTS: It was shown that low proliferative activity and high metastatic potential of LLC correlated with high refractoriness of this tumor to BC1 action, while significant inhibition of tumor growth and metastasis by BC1 were observed against actively proliferating and weakly metastatic LLC-R9. Maximal antitumor activity of BC1 (> 70% of inhibition of primary tumor growth) and antimetastatic action (88% of metastatic inhibition) were observed at the dose of MTD/20. High efficacy of BC1 against LLC-R9 was shown to be accompanied by 2-fold increase of apoptosis rate predominantly in diploid cells. CONCLUSIONS: The obtained results showed the ability of aconitine-containing herbal extract BC1 to inhibit growth of primary tumor and metastases of actively proliferating and weakly metastatic variant of Lewis lung carcinoma.
Authors: D L Kolesnik; O N Pyaskovskaya; O P Gnatyuk; V V Cherepanov; S O Karakhim; I O Polovii; O Yu Posudievsky; N V Konoshchuk; V V Strelchuk; A S Nikolenko; G I Dovbeshko; G I Solyanik Journal: RSC Adv Date: 2021-04-30 Impact factor: 4.036