Literature DB >> 15624988

Convergent approach to (E)-alkene and cyclopropane peptide isosteres.

Peter Wipf1, Jingbo Xiao.   

Abstract

Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These new peptide mimetics can serve as beta-turn promoters.

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Year:  2005        PMID： 15624988     DOI： 10.1021/ol0477529

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents.

Authors:  Peter Wipf; Jingbo Xiao; Corey R J Stephenson
Journal:  Chimia (Aarau)       Date:  2009-11       Impact factor: 1.509

2.  Mitochondrial targeting of radioprotectants using peptidyl conjugates.

Authors:  Anthony Kanai; Irina Zabbarova; Andrew Amoscato; Michael Epperly; Jingbo Xiao; Peter Wipf
Journal:  Org Biomol Chem       Date:  2006-12-07       Impact factor: 3.876

3.  Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold.

Authors:  Jingbo Xiao; Bernard Weisblum; Peter Wipf
Journal:  Org Lett       Date:  2006-10-12       Impact factor: 6.005

4.  Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs.

Authors:  Marie-Céline Frantz; Joshua G Pierce; Joan M Pierce; Li Kangying; Wan Qingwei; Matthew Johnson; Peter Wipf
Journal:  Org Lett       Date:  2011-03-31       Impact factor: 6.005

5.  Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres.

Authors:  Erin M Skoda; Gary C Davis; Peter Wipf
Journal:  Org Process Res Dev       Date:  2012       Impact factor: 3.317

Review 6.  Targeted delivery of radioprotective agents to mitochondria.

Authors:  Irina Zabbarova; Anthony Kanai
Journal:  Mol Interv       Date:  2008-12

7.  Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras.

Authors:  Abhisek Banerjee; Eduard Sergienko; Stefan Vasile; Vineet Gupta; Kristiina Vuori; Peter Wipf
Journal:  Org Lett       Date:  2009-01-01       Impact factor: 6.005
  7 in total

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