Literature DB >> 15624964

TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids.

Arun K Ghosh1, Chun-Xiao Xu, Sarang S Kulkarni, Donald Wink.   

Abstract

TiCl(4)-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized alpha-amino acids with multiple stereogenic centers in good to excellent yields. Cis/trans selectivities with optically active substituted dihydrofurans have been investigated.

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Year:  2005        PMID： 15624964     DOI： 10.1021/ol048302j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction.

Authors:  Arun K Ghosh; Jorden Kass
Journal:  Chem Commun (Camb)       Date:  2010-01-25       Impact factor: 6.222

2.  Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids.

Authors:  Arun K Ghosh; Sarang S Kulkarni; Chun-Xiao Xu; Khriesto Shurrush
Journal:  Tetrahedron Asymmetry       Date:  2008-05-01

3.  TiCl4-promoted tandem carbonyl or imine addition and Friedel-Crafts cyclization: synthesis of benzo-fused oxabicyclooctanes and nonanes.

Authors:  Arun K Ghosh; Cuthbert D Martyr; Chun-Xiao Xu
Journal:  Org Lett       Date:  2012-04-04       Impact factor: 6.005

4.  A stereoselective synthesis of (-)-viridiofungin A utilizing a TiCl(4)-promoted asymmetric multicomponent reaction.

Authors:  Arun K Ghosh; Jorden Kass
Journal:  Org Lett       Date:  2011-12-23       Impact factor: 6.005

5.  Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines.

Authors:  Arun K Ghosh; Sarang Kulkarni; Chun-Xiao Xu; Phillip E Fanwick
Journal:  Org Lett       Date:  2006-09-28       Impact factor: 6.005

6.  Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.

Authors:  Arun K Ghosh
Journal:  J Org Chem       Date:  2010-10-11       Impact factor: 4.354

7.  New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides.

Authors:  Guohua Liang; Laura J Bateman; Nancy I Totah
Journal:  Chem Commun (Camb)       Date:  2009-09-23       Impact factor: 6.222

Review 8.  Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.

Authors:  Arun K Ghosh
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446

9.  Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.

Authors:  Arun K Ghosh; Satyendra Pandey; Sudhakar Gangarajula; Sarang Kulkarni; Xiaoming Xu; Kalapala Venkateswara Rao; Xiangping Huang; Jordan Tang
Journal:  Bioorg Med Chem Lett       Date:  2012-07-20       Impact factor: 2.823
  9 in total

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