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Literature DB >> 15600243

Synthetic peroxides as antimalarials.

Abstract

This review describes the present status of purely synthetic peroxides and 1,2,4-trioxanes and how they perform in various preclinical tests as potential antimalarial drug candidates. The literature is reviewed from 1986 onwards, comprising mostly articles published in the last ten years. As several papers on antimalarial peroxides have already been published, this review focuses on more recent studies detailing the novelty and potential of synthetic peroxides.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 15600243

Source DB: PubMed Journal: Curr Opin Investig Drugs ISSN： 1472-4472

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Cited

7 in total

1. Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.

Authors: Deuk Kyu Moon; Vandana Singhal; Nirbhay Kumar; Theresa A Shapiro; Gary H Posner
Journal: Drug Dev Res Date: 2009-01-01 Impact factor: 4.360

2. A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

Authors: Deuk Kyu Moon; Abhai Tripathi; David Sullivan; Maxime A Siegler; Sean Parkin; Gary H Posner
Journal: Bioorg Med Chem Lett Date: 2010-09-29 Impact factor: 2.823

3. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Authors: Andrew S Rosenthal; Xiaochun Chen; Jun O Liu; Diana C West; Paul J Hergenrother; Theresa A Shapiro; Gary H Posner
Journal: J Med Chem Date: 2009-02-26 Impact factor: 7.446

4. Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

Authors: Yuxiang Dong; Darren Creek; Jacques Chollet; Hugues Matile; Susan A Charman; Sergio Wittlin; James K Wood; Jonathan L Vennerstrom
Journal: Antimicrob Agents Chemother Date: 2007-05-07 Impact factor: 5.191

Synthetic peroxides as antimalarials.

1. Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.

2. A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

3. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

4. Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

5. Preparation of bicyclic 1,2,4-trioxanes from gamma,delta-unsaturated ketones.

6. Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes.

7. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.