Literature DB >> 19132925

Preparation of bicyclic 1,2,4-trioxanes from gamma,delta-unsaturated ketones.

Armando P Ramirez1, Andrew M Thomas, K A Woerpel.   

Abstract

Treatment of gamma,delta-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.

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Year:  2009        PMID： 19132925      PMCID： PMC2657341          DOI： 10.1021/ol8022853

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  22 in total

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2.  Synthesis of 1,2-dioxolanes by annulation reactions of peroxycarbenium ions with alkenes.

Authors:  Armando Ramirez; K A Woerpel
Journal:  Org Lett       Date:  2005-10-13       Impact factor: 6.005

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9.  Alpha-substituted organic peroxides: synthetic strategies for a biologically important class of gem-dihydroperoxide and perketal derivatives.

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Review 10.  Qinghaosu (artemisinin): an antimalarial drug from China.

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Review 2.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

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