Literature DB >> 15582438

Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.

Sachiko Tsukamoto1, Hiroshi Hirota, Misako Imachi, Masahiro Fujimuro, Hiroyuki Onuki, Tomihisa Ohta, Hideyoshi Yokosawa.   

Abstract

A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1-ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 microM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 microM.

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Year:  2005        PMID： 15582438     DOI： 10.1016/j.bmcl.2004.10.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

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Review 2.  Marine-derived Aspergillus species as a source of bioactive secondary metabolites.

Authors:  Yoon Mi Lee; Min Jeong Kim; Huayue Li; Ping Zhang; Baoquan Bao; Ka Jeong Lee; Jee H Jung
Journal:  Mar Biotechnol (NY)       Date:  2013-05-25       Impact factor: 3.619

3.  Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis.

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Review 4.  A patent review of the ubiquitin ligase system: 2015-2018.

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Journal:  Expert Opin Ther Pat       Date:  2018-11-23       Impact factor: 6.674

5.  Homology Modelling of Human E1 Ubiquitin Activating Enzyme.

Authors:  Ghali Brahemi; Angelika M Burger; Andrew D Westwell; Andrea Brancale
Journal:  Lett Drug Des Discov       Date:  2010-01-01       Impact factor: 1.150

Review 6.  Targeting the ubiquitin pathway for cancer treatment.

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Review 7.  Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Biochim Biophys Acta       Date:  2009-03-19

Review 8.  Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.

Authors:  Mariola J Edelmann; Benjamin Nicholson; Benedikt M Kessler
Journal:  Expert Rev Mol Med       Date:  2011-11-17       Impact factor: 5.600

9.  Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1).

Authors:  Dana Ungermannova; Seth J Parker; Christopher G Nasveschuk; Wei Wang; Bettina Quade; Gan Zhang; Robert D Kuchta; Andrew J Phillips; Xuedong Liu
Journal:  PLoS One       Date:  2012-01-18       Impact factor: 3.240

10.  Identification and mechanistic studies of a novel ubiquitin E1 inhibitor.

Authors:  Dana Ungermannova; Seth J Parker; Christopher G Nasveschuk; Douglas A Chapnick; Andrew J Phillips; Robert D Kuchta; Xuedong Liu
Journal:  J Biomol Screen       Date:  2012-01-24
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