Literature DB >> 20396627

Homology Modelling of Human E1 Ubiquitin Activating Enzyme.

Ghali Brahemi1, Angelika M Burger, Andrew D Westwell, Andrea Brancale.   

Abstract

Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

Entities:  

Year:  2010        PMID： 20396627      PMCID： PMC2853970          DOI： 10.2174/157018010789869316

Source DB:  PubMed          Journal:  Lett Drug Des Discov        ISSN： 1570-1808            Impact factor:   1.150


  22 in total

1.  Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

Authors:  Helen Walden; Michael S Podgorski; Brenda A Schulman
Journal:  Nature       Date:  2003-03-20       Impact factor: 49.962

2.  A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

Authors:  Danny T Huang; David W Miller; Rose Mathew; Robert Cassell; James M Holton; Martine F Roussel; Brenda A Schulman
Journal:  Nat Struct Mol Biol       Date:  2004-09-07       Impact factor: 15.369

3.  Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.

Authors:  Luisa Maria Lois; Christopher D Lima
Journal:  EMBO J       Date:  2005-01-20       Impact factor: 11.598

4.  Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.

Authors:  Imsang Lee; Hermann Schindelin
Journal:  Cell       Date:  2008-07-25       Impact factor: 41.582

5.  Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.

Authors:  David Reverter; Christopher D Lima
Journal:  Nature       Date:  2005-06-02       Impact factor: 49.962

6.  Verification of protein structures: patterns of nonbonded atomic interactions.

Authors:  C Colovos; T O Yeates
Journal:  Protein Sci       Date:  1993-09       Impact factor: 6.725

7.  Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.

Authors:  Jianping Jin; Xue Li; Steven P Gygi; J Wade Harper
Journal:  Nature       Date:  2007-06-28       Impact factor: 49.962

8.  Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Authors:  Yili Yang; Jirouta Kitagaki; Ren-Ming Dai; Yien Che Tsai; Kevin L Lorick; Robert L Ludwig; Shervon A Pierre; Jane P Jensen; Ilia V Davydov; Pankaj Oberoi; Chou-Chi H Li; John H Kenten; John A Beutler; Karen H Vousden; Allan M Weissman
Journal:  Cancer Res       Date:  2007-10-01       Impact factor: 12.701

9.  Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme.

Authors:  Ryuichi Sekizawa; Souichi Ikeno; Hikaru Nakamura; Hiroshi Naganawa; Susumu Matsui; Hironobu Iinuma; Tomio Takeuchi
Journal:  J Nat Prod       Date:  2002-10       Impact factor: 4.050

10.  Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.

Authors:  Danny T Huang; Harold W Hunt; Min Zhuang; Melanie D Ohi; James M Holton; Brenda A Schulman
Journal:  Nature       Date:  2007-01-14       Impact factor: 49.962
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  1 in total

1.  Electrophilic adduction of ubiquitin activating enzyme E1 by N,N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat.

Authors:  Olga M Viquez; Samuel W Caito; W Hayes McDonald; David B Friedman; William M Valentine
Journal:  Chem Res Toxicol       Date:  2012-08-22       Impact factor: 3.739
  1 in total

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