Literature DB >> 15571864

Synthesis of 9-acridinyl sulfur derivatives: sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells.

Christiane Santelli-Rouvier1, Jean-Marc Barret, Christopher M Farrell, Derek Sharples, Bridget T Hill, Jacques Barbe.   

Abstract

The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23 compounds prepared, 19 were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is increased 5-10 times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity.

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Year:  2004        PMID： 15571864     DOI： 10.1016/j.ejmech.2004.06.015

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

1.  Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties.

Authors:  Mansour S Al-Said; Mostafa M Ghorab; Yassin M Nissan
Journal:  Chem Cent J       Date:  2012-07-02       Impact factor: 4.215

2.  2-r-(4-Chloro-phen-yl)-6-c-phenyl-3,4,5,6-tetra-hydro-2H-thio-pyran-4-one 1-oxide.

Authors:  A Thiruvalluvar; S Balamurugan; R J Butcher; K Pandiarajan; D Devanathan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-20

3.  Docking studies, synthesis, characterization and evaluation of their antioxidant and cytotoxic activities of some novel isoxazole-substituted 9-anilinoacridine derivatives.

Authors:  R Kalirajan; M H Mohammed Rafick; S Sankar; S Jubie
Journal:  ScientificWorldJournal       Date:  2012-04-19
  3 in total

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