Literature DB >> 15561874

Effects of a number of classes of 50S inhibitors on stop codon readthrough during protein synthesis.

Jill Thompson1, Catherine A Pratt, Albert E Dahlberg.   

Abstract

The effect of a number of antibiotics on stop codon readthrough during protein synthesis in Escherichia coli was examined. Inhibitors which bind close to the entrance of the peptide exit tunnel on the 50S ribosomal subunit promote substantial levels of readthrough, presumably by disrupting the mechanism of peptide release.

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Year:  2004        PMID： 15561874      PMCID： PMC529241          DOI： 10.1128/AAC.48.12.4889-4891.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Structure of the Escherichia coli ribosomal termination complex with release factor 2.

Authors:  Bruno P Klaholz; Tillmann Pape; Andrey V Zavialov; Alexander G Myasnikov; Elena V Orlova; Bente Vestergaard; Måns Ehrenberg; Marin van Heel
Journal:  Nature       Date:  2003-01-02       Impact factor: 49.962

2.  A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA.

Authors:  M O'Connor; H U Göringer; A E Dahlberg
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

3.  The structures of four macrolide antibiotics bound to the large ribosomal subunit.

Authors:  Jeffrey L Hansen; Joseph A Ippolito; Nenad Ban; Poul Nissen; Peter B Moore; Thomas A Steitz
Journal:  Mol Cell       Date:  2002-07       Impact factor: 17.970

4.  Structural basis for the antibiotic activity of ketolides and azalides.

Authors:  Frank Schlünzen; Jörg M Harms; Francois Franceschi; Harly A S Hansen; Heike Bartels; Raz Zarivach; Ada Yonath
Journal:  Structure       Date:  2003-03       Impact factor: 5.006

Review 5.  The quinolones: decades of development and use.

Authors:  A M Emmerson; A M Jones
Journal:  J Antimicrob Chemother       Date:  2003-05       Impact factor: 5.790

6.  Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Authors:  L Xiong; P Kloss; S Douthwaite; N M Andersen; S Swaney; D L Shinabarger; A S Mankin
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

7.  Structural insight into the role of the ribosomal tunnel in cellular regulation.

Authors:  Rita Berisio; Frank Schluenzen; Joerg Harms; Anat Bashan; Tamar Auerbach; David Baram; Ada Yonath
Journal:  Nat Struct Biol       Date:  2003-05

8.  The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome.

Authors:  Tanel Tenson; Martin Lovmar; Måns Ehrenberg
Journal:  J Mol Biol       Date:  2003-07-25       Impact factor: 5.469

9.  A cryo-electron microscopic study of ribosome-bound termination factor RF2.

Authors:  Urmila B S Rawat; Andrey V Zavialov; Jayati Sengupta; Mikel Valle; Robert A Grassucci; Jamie Linde; Bente Vestergaard; Måns Ehrenberg; Joachim Frank
Journal:  Nature       Date:  2003-01-02       Impact factor: 49.962

10.  The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo.

Authors:  Jill Thompson; Michael O'Connor; Jonathan A Mills; Albert E Dahlberg
Journal:  J Mol Biol       Date:  2002-09-13       Impact factor: 5.469
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  15 in total

1.  Multiple defects in translation associated with altered ribosomal protein L4.

Authors:  Michael O'Connor; Steven T Gregory; Albert E Dahlberg
Journal:  Nucleic Acids Res       Date:  2004-10-27       Impact factor: 16.971

Review 2.  SMRT compounds correct nonsense mutations in primary immunodeficiency and other genetic models.

Authors:  Richard A Gatti
Journal:  Ann N Y Acad Sci       Date:  2012-02       Impact factor: 5.691

3.  Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics.

Authors:  Maxim S Svetlov; Nora Vázquez-Laslop; Alexander S Mankin
Journal:  Proc Natl Acad Sci U S A       Date:  2017-12-11       Impact factor: 11.205

4.  Expression of tmRNA in mycobacteria is increased by antimicrobial agents that target the ribosome.

Authors:  Nadya Andini; Kevin A Nash
Journal:  FEMS Microbiol Lett       Date:  2011-08-01       Impact factor: 2.742

Review 5.  How Macrolide Antibiotics Work.

Authors:  Nora Vázquez-Laslop; Alexander S Mankin
Journal:  Trends Biochem Sci       Date:  2018-07-24       Impact factor: 13.807

6.  Regulation of gene expression by macrolide-induced ribosomal frameshifting.

Authors:  Pulkit Gupta; Krishna Kannan; Alexander S Mankin; Nora Vázquez-Laslop
Journal:  Mol Cell       Date:  2013-11-14       Impact factor: 17.970

7.  Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.

Authors:  Güliz Gürel; Gregor Blaha; Thomas A Steitz; Peter B Moore
Journal:  Antimicrob Agents Chemother       Date:  2009-09-08       Impact factor: 5.191

8.  The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.

Authors:  Daniel N Wilson; Frank Schluenzen; Joerg M Harms; Agata L Starosta; Sean R Connell; Paola Fucini
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-29       Impact factor: 11.205

9.  Absence of tmRNA Has a Protective Effect against Fluoroquinolones in Streptococcus pneumoniae.

Authors:  Liliana Brito; Joana Wilton; María J Ferrándiz; Alicia Gómez-Sanz; Adela G de la Campa; Mónica Amblar
Journal:  Front Microbiol       Date:  2017-01-10       Impact factor: 5.640

10.  Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia.

Authors:  Maciej Dabrowski; Zuzanna Bukowy-Bieryllo; Claire L Jackson; Ewa Zietkiewicz
Journal:  Int J Mol Sci       Date:  2021-05-07       Impact factor: 5.923
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