Literature DB >> 15546729

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles.

Ali Almasirad1, Sayyed A Tabatabai, Mehrdad Faizi, Abbas Kebriaeezadeh, Nazila Mehrabi, Afshin Dalvandi, Abbas Shafiee.   

Abstract

A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.

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Year:  2004        PMID： 15546729     DOI： 10.1016/j.bmcl.2004.09.072

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  32 in total

1.  Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.

Authors:  Stesphanie L Breunig; Margaret E Olson; Daniel A Harki
Journal:  Tetrahedron Lett       Date:  2016-07-29       Impact factor: 2.415

2.  4-[(E)-4-Bromo-benzyl-ideneamino]-3-[1-(4-isobutyl-phen-yl)eth-yl]-1H-1,2,4-triazole-5(4H)-thione.

Authors:  Hoong-Kun Fun; Samuel Robinson Jebas; K V Sujith; Balakrishna Kalluraya
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-20

3.  4-[(E)-2,6-Dichloro-benzyl-ideneamino]-3-{1-[4-(2-methyl-prop-yl)phen-yl]eth-yl}-1H-1,2,4-triazole-5(4H)-thione.

Authors:  Hoong-Kun Fun; Suchada Chantrapromma; K V Sujith; P S Patil; B Kalluraya; A Muralidharan; S M Dharmaprakash
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-07-16

4.  3-Benzamidomethyl-4-[(E)-2-chloro-benzyl-ideneamino]-1H-1,2,4-triazole-5(4H)-thione.

Authors:  Hoong-Kun Fun; Samuel Robinson Jebas; Jyothi N Rao; B Kalluraya
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-12-10

5.  5-[1-(3,4-Dichloro-phen-oxy)eth-yl]-1,3,4-oxadiazole-2(3H)-thione hemihydrate.

Authors:  Tashfeen Akhtar; M Khawar Rauf; Shahid Hameed; Xiaoming Lu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-08

6.  (E)-3-Methyl-4-[(2-oxidoquinolin-1-ium-3-yl)methyl-eneamino]-1H-1,2,4-triazole-5(4H)-thione N,N-dimethyl-formamide solvate.

Authors:  Jia Hao Goh; Hoong-Kun Fun; Adithya Adhikari; B Kalluraya
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-28

7.  Studies on Absorption and Emission Characteristics of Inclusion Complexes of Some 4-Arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols.

Authors:  Sunakar Panda; Sashikanta Nayak
Journal:  J Fluoresc       Date:  2015-11-21       Impact factor: 2.217

8.  Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives.

Authors:  Akhilesh Kumar; Saritha S D'Souza; S L Gaonkar; K M L Rai; Bharathi P Salimath
Journal:  Invest New Drugs       Date:  2008-01-29       Impact factor: 3.850

9.  Design, synthesis, and preliminary pharmacological evaluation of novel thiazolidinone derivatives as potential benzodiazepine agonists.

Authors:  Ali Almasirad; Maryam Ghadimi; Saeideh Mirahmadi; Pouya Ahmadian Kodakan; Reza Jahani; Maryam Nazari; Elham Rezaee; Homa Azizian; Parmida Rabizadeh; Sayyed Abbas Tabatabai; Mehrdad Faizi
Journal:  Mol Divers       Date:  2021-01-23       Impact factor: 2.943

10.  Synthesis and evaluation of antitumor activities of novel chiral 1,2,4-triazole Schiff bases bearing γ-butenolide moiety.

Authors:  Xiang Li; Xue-Qiang Li; He-Mei Liu; Xue-Zhang Zhou; Zhi-Hui Shao
Journal:  Org Med Chem Lett       Date:  2012-07-03
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