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Literature DB >> 15539529

Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus.

Catrin E Moore¹, Shelley Segal, Anthony R Berendt, Adrian V S Hill, Nicholas P J Day.

Abstract

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15539529 PMCID： PMC524778 DOI： 10.1128/CDLI.11.6.1194-1197.2004

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

12 in total

1. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Authors: O Takeuchi; K Hoshino; T Kawai; H Sanjo; H Takada; T Ogawa; K Takeda; S Akira
Journal: Immunity Date: 1999-10 Impact factor: 31.745

2. The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus.

Authors: Daisuke Iwaki; Hiroaki Mitsuzawa; Seiji Murakami; Hitomi Sano; Masanori Konishi; Toyoaki Akino; Yoshio Kuroki
Journal: J Biol Chem Date: 2002-05-01 Impact factor: 5.157

3. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.

Authors: T J Kang; G T Chae
Journal: FEMS Immunol Med Microbiol Date: 2001-07

4. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.

Authors: O Takeuchi; K Hoshino; S Akira
Journal: J Immunol Date: 2000-11-15 Impact factor: 5.422

5. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection.

Authors: E Lorenz; J P Mira; K L Cornish; N C Arbour; D A Schwartz
Journal: Infect Immun Date: 2000-11 Impact factor: 3.441

6. Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses.

Authors: Sonja von Aulock; Nicolas W J Schröder; Stephanie Traub; Katja Gueinzius; Eva Lorenz; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Journal: Infect Immun Date: 2004-03 Impact factor: 3.441

7. Involvement of leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycans.

Authors: Mari Fujita; Takeshi Into; Motoaki Yasuda; Tsugumi Okusawa; Sumiko Hamahira; Yoshio Kuroki; Akiko Eto; Toshiki Nisizawa; Manabu Morita; Ken-ichiro Shibata
Journal: J Immunol Date: 2003-10-01 Impact factor: 5.422

8. Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus.

Authors: Nilufer Esen; Flobert Y Tanga; Joyce A DeLeo; Tammy Kielian
Journal: J Neurochem Date: 2004-02 Impact factor: 5.372

9. Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent.

Authors: Martin Mempel; Verena Voelcker; Gabriele Köllisch; Christian Plank; Roland Rad; Markus Gerhard; Christina Schnopp; Peter Fraunberger; Autar K Walli; Johannes Ring; Dietrich Abeck; Markus Ollert
Journal: J Invest Dermatol Date: 2003-12 Impact factor: 8.551

10. A microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene: functional implications and racial differences.

Authors: Jae-Joon Yim; Li Ding; Alejandro A Schäffer; Gye Young Park; Young-Soo Shim; Steven M Holland
Journal: FEMS Immunol Med Microbiol Date: 2004-03-08

24 in total

Review 1. Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.

Authors: Mamoona Noreen; Muhammad Arshad
Journal: Immunol Res Date: 2015-06 Impact factor: 2.829

2. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

Authors: Asmaa Abu-Maziad; Kendra Schaa; Edward F Bell; John M Dagle; Margaret Cooper; Mary L Marazita; Jeffrey C Murray
Journal: Pediatr Res Date: 2010-10 Impact factor: 3.756

3. Association of TLR-4 and TNF-alpha polymorphisms with clinical symptoms and cytokine levels in patients with allergic rhinitis.

Authors: Magdolna Krasznai; Kinga Szaniszlo; Helga Kraxner; Eszter Vargha; Margit Kovacs; Zoltan Borocz; Edit Kaszas; Gyorgyi Mezei; Endre Cserhati; Karoly Cseh
Journal: Eur Arch Otorhinolaryngol Date: 2010-11-20 Impact factor: 2.503

Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus.

1. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

2. The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus.

3. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.

4. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.

5. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection.

6. Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses.

7. Involvement of leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycans.

8. Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus.

9. Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent.

10. A microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene: functional implications and racial differences.

Review 1. Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.

2. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

3. Association of TLR-4 and TNF-alpha polymorphisms with clinical symptoms and cytokine levels in patients with allergic rhinitis.

Review 4. Recognition of Staphylococcus aureus by the innate immune system.

Review 5. Genetics and genomics in pediatric septic shock.

6. Toll-like receptor 2 gene polymorphisms Arg677Trp and Arg753Gln in chronic obstructive pulmonary disease.

Review 7. Severe sepsis and Toll-like receptors.

Review 8. Divergent functions of Toll-like receptors during bacterial lung infections.

Review 9. The role of Toll-like receptor signaling in human immunodeficiencies.

Review 10. Bench-to-bedside review: Association of genetic variation with sepsis.