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Literature DB >> 25784622

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.

Abstract

Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.

Entities: Gene

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Year: 2015 PMID： 25784622 DOI： 10.1007/s12026-015-8640-6

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

238 in total

1. Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.

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Journal: Pediatr Infect Dis J Date: 2003-11 Impact factor: 2.129

2. The road to Toll.

Authors: Bruno Lemaitre
Journal: Nat Rev Immunol Date: 2004-07 Impact factor: 53.106

3. A toll-like receptor that prevents infection by uropathogenic bacteria.

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Journal: Science Date: 2004-03-05 Impact factor: 47.728

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Authors: Vu V'et Kuong; D S Avetikov; O A Shlykova; O V Izmaĭlova; I P Kaĭdashev
Journal: Klin Khir Date: 2014-10

5. Toll-like receptor 4 (TLR4) polymorphisms in Iranian patients with visceral leishmaniasis.

Authors: Manoochehr Rasouli; Maryam Keshavarz; Mehdi Kalani; Ali Moravej; Simin Kiany; Parisa Badiee
Journal: Mol Biol Rep Date: 2012-10-06 Impact factor: 2.316

6. Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.

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Journal: J Infect Dis Date: 2006-06-13 Impact factor: 5.226

7. Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees.

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Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

8. High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR.

Authors: Nicolas W J Schröder; Corinna Hermann; Lutz Hamann; Ulf B Göbel; Thomas Hartung; Ralf R Schumann
Journal: J Mol Med (Berl) Date: 2003-05-13 Impact factor: 4.599

9. Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.

Authors: Pierre-Yves Bochud; Thomas R Hawn; M Ruby Siddiqui; Paul Saunderson; Sven Britton; Isaac Abraham; Azeb Tadesse Argaw; Marta Janer; Lue Ping Zhao; Gilla Kaplan; Alan Aderem
Journal: J Infect Dis Date: 2008-01-15 Impact factor: 5.226

10. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.

Authors: John Castiblanco; Diana-Cristina Varela; Natalia Castaño-Rodríguez; Adriana Rojas-Villarraga; María-Eugenia Hincapié; Juan-Manuel Anaya
Journal: Infect Genet Evol Date: 2008-03-12 Impact factor: 3.342

29 in total

1. IFN-τ Alleviates Lipopolysaccharide-Induced Inflammation by Suppressing NF-κB and MAPKs Pathway Activation in Mice.

Authors: Haichong Wu; Gan Zhao; Kangfeng Jiang; Xiuying Chen; Guangze Rui; Changwei Qiu; Mengyao Guo; Ganzhen Deng
Journal: Inflammation Date: 2016-06 Impact factor: 4.092

2. Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families.

Authors: Farook Thameem; Sobha Puppala; Vidya S Farook; Balakuntalam S Kasinath; John Blangero; Ravindranath Duggirala; Hanna E Abboud
Journal: Cardiorenal Med Date: 2016-05-20 Impact factor: 2.041

3. Identification of Systems Level Molecular Signatures from Glioblastoma Multiforme Derived Extracellular Vesicles.

Authors: Nabanita Roy; Mithil Gaikwad; Dhruba Kr Bhattacharrya; Pankaj Barah
Journal: J Mol Neurosci Date: 2020-11-24 Impact factor: 3.444

4. MYD88 and functionally related genes are associated with multiple infections in a model population of Kenyan village dogs.

Authors: Michaela Necesankova; Leona Vychodilova; Katerina Albrechtova; Lorna J Kennedy; Jan Hlavac; Kamil Sedlak; David Modry; Eva Janova; Mirko Vyskocil; Petr Horin
Journal: Mol Biol Rep Date: 2016-09-21 Impact factor: 2.316

5. MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.

Authors: Jiabin Liu; Rui-Xi Hua; Wen Fu; Jinhong Zhu; Wei Jia; Jiao Zhang; Haixia Zhou; Jiwen Cheng; Huimin Xia; Guochang Liu; Jing He
Journal: Ann Transl Med Date: 2019-09

6. TLR4 polymorphisms as potential predictors of atopic dermatitis in Chinese Han children.

Authors: Jianrong Shi; Lin He; Ran Tao; Huiwen Zheng; Wei Li; Shuangshuang Huang; Yunling Li; Shiqiang Shang
Journal: J Clin Lab Anal Date: 2022-03-29 Impact factor: 3.124

7. Effect of smoking on the genetic makeup of toll-like receptors 2 and 6.

Authors: Muhammad Kohailan; Mohammad Alanazi; Mahmoud Rouabhia; Abdullah Alamri; Narasimha Reddy Parine; Abdullah Alhadheq; Santhosh Basavarajappa; Abdul Aziz Abdullah Al-Kheraif; Abdelhabib Semlali
Journal: Onco Targets Ther Date: 2016-11-21 Impact factor: 4.147

8. The Expression of Toll-like receptors in eutopic and ectopic endometrium and its implication in the inflammatory pathogenesis of adenomyosis.

Authors: Caixia Jiang; Chao Liu; Jing Guo; Li Chen; Ning Luo; Xiaoyan Qu; Weihong Yang; Qing Ren; Zhongping Cheng
Journal: Sci Rep Date: 2017-08-04 Impact factor: 4.379

9. IFN-τ Mediated Control of Bovine Major Histocompatibility Complex Class I Expression and Function via the Regulation of bta-miR-148b/152 in Bovine Endometrial Epithelial Cells.

Authors: Haichong Wu; Kangfeng Jiang; Shuai Guo; Jing Yang; Gan Zhao; Changwei Qiu; Ganzhen Deng
Journal: Front Immunol Date: 2018-02-02 Impact factor: 7.561

Review 10. TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review.

Authors: Asma Komal; Mamoona Noreen; Attalla F El-Kott
Journal: Immunol Res Date: 2021-06-19 Impact factor: 2.829