Literature DB >> 14977997

Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses.

Sonja von Aulock1, Nicolas W J Schröder, Stephanie Traub, Katja Gueinzius, Eva Lorenz, Thomas Hartung, Ralf R Schumann, Corinna Hermann.   

Abstract

While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 14977997      PMCID： PMC356018          DOI： 10.1128/IAI.72.3.1828-1831.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  10 in total

1.  Toll-like receptors.

Authors:  Egil Lien; Robin R. Ingalls
Journal:  Crit Care Med       Date:  2002-01       Impact factor: 7.598

2.  Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood.

Authors:  Sonja von Aulock; Nicolas W J Schröder; Katja Gueinzius; Stephanie Traub; Sebastian Hoffmann; Kathrin Graf; Stefanie Dimmeler; Thomas Hartung; Ralf R Schumann; Corinna Hermann
Journal:  J Infect Dis       Date:  2003-08-28       Impact factor: 5.226

3.  Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release.

Authors:  Corinna Hermann; Ingo Spreitzer; Nicolas W J Schröder; Siegfried Morath; Martin D Lehner; Werner Fischer; Christine Schütt; Ralf R Schumann; Thomas Hartung
Journal:  Eur J Immunol       Date:  2002-02       Impact factor: 5.532

4.  Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators.

Authors:  M D Lehner; S Morath; K S Michelsen; R R Schumann; T Hartung
Journal:  J Immunol       Date:  2001-04-15       Impact factor: 5.422

5.  Structural decomposition and heterogeneity of commercial lipoteichoic Acid preparations.

Authors:  Siegfried Morath; Armin Geyer; Ingo Spreitzer; Corinna Hermann; Thomas Hartung
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

6.  A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection.

Authors:  E Lorenz; J P Mira; K L Cornish; N C Arbour; D A Schwartz
Journal:  Infect Immun       Date:  2000-11       Impact factor: 3.441

7.  High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR.

Authors:  Nicolas W J Schröder; Corinna Hermann; Lutz Hamann; Ulf B Göbel; Thomas Hartung; Ralf R Schumann
Journal:  J Mol Med (Berl)       Date:  2003-05-13       Impact factor: 4.599

8.  Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus.

Authors:  S Morath; A Geyer; T Hartung
Journal:  J Exp Med       Date:  2001-02-05       Impact factor: 14.307

9.  Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release.

Authors:  Siegfried Morath; Andreas Stadelmaier; Armin Geyer; Richard R Schmidt; Thomas Hartung
Journal:  J Exp Med       Date:  2002-06-17       Impact factor: 14.307

10.  Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.

Authors:  Clett Erridge; John Stewart; Ian R Poxton
Journal:  J Exp Med       Date:  2003-06-09       Impact factor: 14.307
  10 in total
  14 in total

1.  Quantitative Fundus Autofluorescence and Optical Coherence Tomography in ABCA4 Carriers.

Authors:  Tobias Duncker; Gregory E Stein; Winston Lee; Stephen H Tsang; Jana Zernant; Srilaxmi Bearelly; Donald C Hood; Vivienne C Greenstein; François C Delori; Rando Allikmets; Janet R Sparrow
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-11       Impact factor: 4.799

2.  Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus.

Authors:  Catrin E Moore; Shelley Segal; Anthony R Berendt; Adrian V S Hill; Nicholas P J Day
Journal:  Clin Diagn Lab Immunol       Date:  2004-11

Review 3.  Herpesviral infection and Toll-like receptor 2.

Authors:  Ming-sheng Cai; Mei-li Li; Chun-fu Zheng
Journal:  Protein Cell       Date:  2012-08-04       Impact factor: 14.870

4.  Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population.

Authors:  Marija Perica; Mandica Vidović; Lovro Lamot; Lana Tambić Bukovac; Sanja Kapitanović; Magdalena Perić; Jerko Barbić; Miroslav Harjaček
Journal:  Clin Rheumatol       Date:  2015-04-30       Impact factor: 2.980

Review 5.  Recognition of Staphylococcus aureus by the innate immune system.

Authors:  Bénédicte Fournier; Dana J Philpott
Journal:  Clin Microbiol Rev       Date:  2005-07       Impact factor: 26.132

Review 6.  Genetics and genomics in pediatric septic shock.

Authors:  Hector R Wong
Journal:  Crit Care Med       Date:  2012-05       Impact factor: 7.598

Review 7.  Genetic variants of innate immune receptors and infections after liver transplantation.

Authors:  Gemma Sanclemente; Asuncion Moreno; Miquel Navasa; Francisco Lozano; Carlos Cervera
Journal:  World J Gastroenterol       Date:  2014-08-28       Impact factor: 5.742

8.  The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.

Authors:  Robert A Brown; Jonathon H Gralewski; Raymund R Razonable
Journal:  Clin Infect Dis       Date:  2009-11-01       Impact factor: 9.079

Review 9.  Relevance of single-nucleotide polymorphisms in human TLR genes to infectious and inflammatory diseases and cancer.

Authors:  A Trejo-de la O; P Hernández-Sancén; C Maldonado-Bernal
Journal:  Genes Immun       Date:  2014-03-13       Impact factor: 2.676

10.  Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection.

Authors:  Mangesh R Bhide; Rastislav Mucha; Ivan Mikula; Lucia Kisova; Rostislav Skrabana; Michal Novak; Ivan Mikula
Journal:  BMC Genet       Date:  2009-05-26       Impact factor: 2.797
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.