AIMS: To determine the accuracy of Bilicheck in assessing serum bilirubin. To evaluate the effectiveness of Bilicheck as a screening device in a population of jaundiced term and near-term babies. METHODS: Prospective evaluation of paired Bilicheck measurements and serum bilirubin in 300 babies. RESULTS: There was a strong correlation between Bilicheck and serum bilirubin. The mean difference between Bilicheck and serum bilirubin was -10.7 micromol/l, but the 95% limits of agreement were wide at -80 micromol/l to +60 micromol/l. Bilicheck identified significant jaundice (serum bilirubin above 250 micromol/l) with a sensitivity (95% confidence interval) of 91% (88% to 94%) and specificity of 66% (60% to 71%). The area under the receiver operator characteristic curve was 0.85. There were five false negatives, all of whom had a serum bilirubin below 300 micromol/l. If Bilicheck had been used as a screening device, there would have been a 55% decrease in blood samples taken in these babies. CONCLUSION: Bilicheck cannot be used to measure serum bilirubin in term and near-term babies with jaundice, but is an effective screening method, which can be used to safely reduce the number of blood tests in these babies.
AIMS: To determine the accuracy of Bilicheck in assessing serum bilirubin. To evaluate the effectiveness of Bilicheck as a screening device in a population of jaundiced term and near-term babies. METHODS: Prospective evaluation of paired Bilicheck measurements and serum bilirubin in 300 babies. RESULTS: There was a strong correlation between Bilicheck and serum bilirubin. The mean difference between Bilicheck and serum bilirubin was -10.7 micromol/l, but the 95% limits of agreement were wide at -80 micromol/l to +60 micromol/l. Bilicheck identified significant jaundice (serum bilirubin above 250 micromol/l) with a sensitivity (95% confidence interval) of 91% (88% to 94%) and specificity of 66% (60% to 71%). The area under the receiver operator characteristic curve was 0.85. There were five false negatives, all of whom had a serum bilirubin below 300 micromol/l. If Bilicheck had been used as a screening device, there would have been a 55% decrease in blood samples taken in these babies. CONCLUSION: Bilicheck cannot be used to measure serum bilirubin in term and near-term babies with jaundice, but is an effective screening method, which can be used to safely reduce the number of blood tests in these babies.
Authors: James A Taylor; Anthony E Burgos; Valerie Flaherman; Esther K Chung; Elizabeth A Simpson; Neera K Goyal; Isabelle Von Kohorn; Niramol Dhepyasuwan Journal: Pediatrics Date: 2016-04-06 Impact factor: 7.124
Authors: James A Taylor; James W Stout; Lilian de Greef; Mayank Goel; Shwetak Patel; Esther K Chung; Aruna Koduri; Shawn McMahon; Jane Dickerson; Elizabeth A Simpson; Eric C Larson Journal: Pediatrics Date: 2017-09 Impact factor: 7.124
Authors: L Murli; A Thukral; M J Sankar; S Vishnubhatla; A K Deorari; V K Paul; A Sakariah; R Agarwal Journal: J Perinatol Date: 2016-10-20 Impact factor: 2.521
Authors: James A Taylor; Anthony E Burgos; Valerie Flaherman; Esther K Chung; Elizabeth A Simpson; Neera K Goyal; Isabelle Von Kohorn; Nui Dhepyasuwan Journal: Pediatrics Date: 2015-01-19 Impact factor: 7.124