Literature DB >> 15507374

Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

Theodore A Bischoff1, Charles J Kelley, Yvette Karchesy, Maria Laurantos, Phuc Nguyen-Dinh, Abdul Ghafoor Arefi.   

Abstract

Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.

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Year:  2004        PMID： 15507374     DOI： 10.1016/j.jep.2004.06.031

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  30 in total

Review 1.  Ethnomedicinal Uses, Phytochemistry and Pharmacology of Different Cichorium Species (Asteraceae): A Review.

Authors:  Zahra Boghrati; Elaheh Zibaee; Zahra Ayati; Mohammad Sadegh Amiri; Mahin Ramezani; Tannaz Jamialahmadi; Seyed Ahmad Emami; Amirhossein Sahebkar
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

2.  The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.

Authors:  Jared N Balaich; Derrick K Mathias; Baldwyn Torto; Bryan T Jackson; Dingyin Tao; Babak Ebrahimi; Brian B Tarimo; Xavier Cheseto; Woodbridge A Foster; Rhoel R Dinglasan
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

3.  Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats.

Authors:  Guo-Yu Li; Hong-Ying Gao; Jian Huang; Jin Lu; Jing-Kai Gu; Jin-Hui Wang
Journal:  World J Gastroenterol       Date:  2014-04-28       Impact factor: 5.742

Review 4.  Medical Plant Extracts for Treating Knee Osteoarthritis: a Snapshot of Recent Clinical Trials and Their Biological Background.

Authors:  Sonja M Walzer; Daniela Weinmann; Stefan Toegel
Journal:  Curr Rheumatol Rep       Date:  2015-08       Impact factor: 4.592

5.  Discovery of potential mTOR inhibitors from Cichorium intybus to find new candidate drugs targeting the pathological protein related to the breast cancer: an integrated computational approach.

Authors:  Hezha O Rasul; Bakhtyar K Aziz; Dlzar D Ghafour; Arif Kivrak
Journal:  Mol Divers       Date:  2022-06-23       Impact factor: 2.943

Review 6.  A natural history of botanical therapeutics.

Authors:  Barbara Schmidt; David M Ribnicky; Alexander Poulev; Sithes Logendra; William T Cefalu; Ilya Raskin
Journal:  Metabolism       Date:  2008-07       Impact factor: 8.694

7.  Silencing of germacrene A synthase genes reduces guaianolide oxalate content in Cichorium intybus L.

Authors:  Milica Bogdanović; Katarina Cankar; Milan Dragićević; Harro Bouwmeester; Jules Beekwilder; Ana Simonović; Slađana Todorović
Journal:  GM Crops Food       Date:  2019-10-31       Impact factor: 3.074

8.  Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots.

Authors:  João P Baixinho; José D Anastácio; Viktoriya Ivasiv; Katarina Cankar; Dirk Bosch; Regina Menezes; Matthew de Roode; Cláudia Nunes Dos Santos; Ana A Matias; Naiara Fernández
Journal:  Molecules       Date:  2021-04-28       Impact factor: 4.411

9.  Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum.

Authors:  Wei-Jun Yang; Yu-Qin Luo; Haji Akber Aisa; Xue-Lei Xin; Z Totahon; Yan Mao; Meng-Ying Hu; Lei Xu; Rui-Ping Zhang
Journal:  Chin Med       Date:  2012-09-29       Impact factor: 5.455

10.  Artificial semi-rigid tissue sensitized with natural pigments: Effect of photon radiations.

Authors:  Adnan Jaradat; M-Ali H Al-Akhras; G Makhadmeh; K Aljarrah; A Al-Omari; Z Ababneh; Majed M Masadeh; H M Al-Khateeb; B A Albiss; M Alshorman
Journal:  J Pharm Bioallied Sci       Date:  2011-04
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