Literature DB >> 16641474

Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates.

Claudia Plinke1, Sabine Rüsch-Gerdes, Stefan Niemann.   

Abstract

We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.

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Year:  2006        PMID： 16641474      PMCID： PMC1472212          DOI： 10.1128/AAC.50.5.1900-1902.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community.

Authors:  A Van Rie ; R Warren; I Mshanga; A M Jordaan; G D van der Spuy ; M Richardson; J Simpson; R P Gie; D A Enarson; N Beyers; P D van Helden ; T C Victor
Journal:  J Clin Microbiol       Date:  2001-02       Impact factor: 5.948

2.  Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.

Authors:  S Sreevatsan; K E Stockbauer; X Pan; B N Kreiswirth; S L Moghazeh; W R Jacobs; A Telenti; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.

Authors:  S V Ramaswamy; A G Amin; S Göksel; C E Stager; S J Dou; H El Sahly; S L Moghazeh; B N Kreiswirth; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

4.  Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.

Authors:  Ann S G Lee; Siti Noor Khadijah Othman; Yu Min Ho; Sin Yew Wong
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

5.  A Pyrosequencing assay for rapid recognition of SNPs in Mycobacterium tuberculosis embB306 region.

Authors:  Daniela Isola; Manuela Pardini; Francis Varaine; Stefan Niemann; Sabine Rüsch-Gerdes; Lanfranco Fattorini; Graziella Orefici; Francesca Meacci; Claudia Trappetti; Marco Rinaldo Oggioni; Germano Orrù
Journal:  J Microbiol Methods       Date:  2005-07       Impact factor: 2.363

6.  Characterisation of rpsL, rrs and embB mutations associated with streptomycin and ethambutol resistance in Mycobacterium tuberculosis.

Authors:  Tatjana Tracevska; Inta Jansone; Anda Nodieva; Olgerts Marga; Girts Skenders; Viesturs Baumanis
Journal:  Res Microbiol       Date:  2004-12       Impact factor: 3.992

7.  Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.

Authors:  Manzour Hernando Hazbón; Miriam Bobadilla del Valle; Marta Inírida Guerrero; Mandira Varma-Basil; Ingrid Filliol; Magali Cavatore; Roberto Colangeli; Hassan Safi; Helen Billman-Jacobe; Caroline Lavender; Janet Fyfe; Lourdes García-García; Amy Davidow; Michael Brimacombe; Clara Inés León; Tania Porras; Mridula Bose; Fernando Chaves; Kathleen D Eisenach; José Sifuentes-Osornio; Alfredo Ponce de León; M Donald Cave; David Alland
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

8.  Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutol.

Authors:  Linda M Parsons; Max Salfinger; Anne Clobridge; Jillian Dormandy; Lisa Mirabello; Valerie L Polletta; Ahmet Sanic; Oleg Sinyavskiy; Susan C Larsen; Jeffrey Driscoll; Genet Zickas; Harry W Taber
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

Review 9.  Laboratory diagnostic aspects of drug resistant tuberculosis.

Authors:  Linda M Parsons; Akos Somoskövi; Richard Urbanczik; Max Salfinger
Journal:  Front Biosci       Date:  2004-09-01

10.  Detection of embB306 mutations in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis from Northwestern Russia: implications for genotypic resistance testing.

Authors:  Igor Mokrousov; Tatiana Otten; Boris Vyshnevskiy; Olga Narvskaya
Journal:  J Clin Microbiol       Date:  2002-10       Impact factor: 5.948
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  31 in total

1.  GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples.

Authors:  A Lacoma; N García-Sierra; C Prat; J Maldonado; J Ruiz-Manzano; L Haba; P Gavin; S Samper; V Ausina; J Domínguez
Journal:  J Clin Microbiol       Date:  2011-11-09       Impact factor: 5.948

2.  Detection by GenoType MTBDRsl test of complex mechanisms of resistance to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates.

Authors:  Florence Brossier; Nicolas Veziris; Alexandra Aubry; Vincent Jarlier; Wladimir Sougakoff
Journal:  J Clin Microbiol       Date:  2010-03-24       Impact factor: 5.948

3.  Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.

Authors:  Qing Sun; Tong-Yang Xiao; Hai-Can Liu; Xiu-Qin Zhao; Zhi-Guang Liu; Ya-Nan Li; Hao Zeng; Li-Li Zhao; Kang-Lin Wan
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

4.  Molecular Analysis of the embCAB Locus and embR Gene Involved in Ethambutol Resistance in Clinical Isolates of Mycobacterium tuberculosis in France.

Authors:  Florence Brossier; Wladimir Sougakoff; Christine Bernard; Matthieu Petrou; Karine Adeyema; Anne Pham; Diane Amy de la Breteque; Marine Vallet; Vincent Jarlier; Christophe Sola; Nicolas Veziris
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

5.  Performance Assessment of the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Rapid Detection of Susceptibility to Ethambutol and Molecular Prediction of Extensively Drug-resistant Tuberculosis in Clinical Isolates of Mycobacterium tuberculosis.

Authors:  M Arjomandzadegan; R Nazari; M R Zolfaghari; M Taherahmadi; M Sadrnia; L P Titov; A Ahmadi; M Shojapoor
Journal:  West Indian Med J       Date:  2015-06-12       Impact factor: 0.171

6.  Mutation at embB codon 306, a potential marker for the identification of multidrug resistance associated with ethambutol in Mycobacterium tuberculosis.

Authors:  Betzaida Cuevas-Córdoba; Dulce María Juárez-Eusebio; Raquel Almaraz-Velasco; Raquel Muñiz-Salazar; Rafael Laniado-Laborin; Roberto Zenteno-Cuevas
Journal:  Antimicrob Agents Chemother       Date:  2015-06-29       Impact factor: 5.191

7.  Feasibility of the GenoType MTBDRsl assay for fluoroquinolone, amikacin-capreomycin, and ethambutol resistance testing of Mycobacterium tuberculosis strains and clinical specimens.

Authors:  Doris Hillemann; Sabine Rüsch-Gerdes; Elvira Richter
Journal:  J Clin Microbiol       Date:  2009-04-22       Impact factor: 5.948

8.  Association between embB Codon 306 Mutations, Phenotypic Resistance Profiles, and Genotypic Characterization in Clinical Mycobacterium tuberculosis Isolates from Hebei, China.

Authors:  Yanan Li; Yuling Wang; Zhi Zhang; Huixia Gao; Haibin Wang; Jinfeng Cao; Shumin Zhang; Yuzhen Liu; Jianhua Lu; Zungui Xu; Erhei Dai
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

9.  Convergent evolutionary analysis identifies significant mutations in drug resistance targets of Mycobacterium tuberculosis.

Authors:  Manzour Hernando Hazbón; Alifiya S Motiwala; Magali Cavatore; Michael Brimacombe; Thomas S Whittam; David Alland
Journal:  Antimicrob Agents Chemother       Date:  2008-06-30       Impact factor: 5.191

10.  Mutations at embB codon 306 are an important molecular indicator of ethambutol resistance in Mycobacterium tuberculosis.

Authors:  Angela M Starks; Aysel Gumusboga; Bonnie B Plikaytis; Thomas M Shinnick; James E Posey
Journal:  Antimicrob Agents Chemother       Date:  2008-12-22       Impact factor: 5.191
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