| Literature DB >> 10655480 |
D A Bochar1, J Savard, W Wang, D W Lafleur, P Moore, J Côté, R Shiekhattar.
Abstract
Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.Entities:
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Year: 2000 PMID： 10655480 PMCID： PMC15513 DOI： 10.1073/pnas.97.3.1038
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205