Literature DB >> 15489970

Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis.

Russell J Cox1, Frank Glod, Deirdre Hurley, Colin M Lazarus, Thomas P Nicholson, Brian A M Rudd, Thomas J Simpson, Barrie Wilkinson, Ying Zhang.   

Abstract

PCR primers designed to selectively amplify the unique C-methyltransferase domain of fungal polyketide synthases were used to selectively clone a polyketide synthase gene involved in the biosynthesis of the squalene synthase inhibitor squalestatin S1 , heterologous expression of which led to the biosynthesis of the squalestatin side-chain.

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Year:  2004        PMID： 15489970     DOI： 10.1039/b411973h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

Review 1.  Biosynthesis of sphinganine-analog mycotoxins.

Authors:  L Du; X Zhu; R Gerber; J Huffman; L Lou; J Jorgenson; F Yu; K Zaleta-Rivera; Q Wang
Journal:  J Ind Microbiol Biotechnol       Date:  2008-01-24       Impact factor: 3.346

Review 2.  Strategies for mining fungal natural products.

Authors:  Philipp Wiemann; Nancy P Keller
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-22       Impact factor: 3.346

3.  Functional replacement of the ketosynthase domain of FUM1 for the biosynthesis of fumonisins, a group of fungal reduced polyketides.

Authors:  X Zhu; F Yu; R S Bojja; K Zaleta-Rivera; L Du
Journal:  J Ind Microbiol Biotechnol       Date:  2006-05-09       Impact factor: 3.346

Review 4.  The architectures of iterative type I PKS and FAS.

Authors:  Dominik A Herbst; Craig A Townsend; Timm Maier
Journal:  Nat Prod Rep       Date:  2018-10-17       Impact factor: 13.423

Review 5.  Unraveling polyketide synthesis in members of the genus Aspergillus.

Authors:  Yi-Ming Chiang; Berl R Oakley; Nancy P Keller; Clay C C Wang
Journal:  Appl Microbiol Biotechnol       Date:  2010-04-02       Impact factor: 4.813

6.  An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans.

Authors:  Yi-Ming Chiang; C Elizabeth Oakley; Manmeet Ahuja; Ruth Entwistle; Aric Schultz; Shu-Lin Chang; Calvin T Sung; Clay C C Wang; Berl R Oakley
Journal:  J Am Chem Soc       Date:  2013-05-09       Impact factor: 15.419

7.  Navigating the fungal polyketide chemical space: from genes to molecules.

Authors:  Yit-Heng Chooi; Yi Tang
Journal:  J Org Chem       Date:  2012-09-13       Impact factor: 4.354

8.  Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway.

Authors:  Nicholas Liu; Yiu-Sun Hung; Shu-Shan Gao; Leibniz Hang; Yi Zou; Yit-Heng Chooi; Yi Tang
Journal:  Org Lett       Date:  2017-06-13       Impact factor: 6.005

9.  Acyltransferase mediated polyketide release from a fungal megasynthase.

Authors:  Xinkai Xie; Michael J Meehan; Wei Xu; Pieter C Dorrestein; Yi Tang
Journal:  J Am Chem Soc       Date:  2009-06-24       Impact factor: 15.419

10.  Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis.

Authors:  Li Chen; Qun Yue; Xinyu Zhang; Meichun Xiang; Chengshu Wang; Shaojie Li; Yongsheng Che; Francisco Javier Ortiz-López; Gerald F Bills; Xingzhong Liu; Zhiqiang An
Journal:  BMC Genomics       Date:  2013-05-20       Impact factor: 3.969
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