Literature DB >> 15482917

Synthesis and antitumor activity of 4-hydroxycoumarin derivatives.

Jae-Chul Jung1, Ji-Ho Lee, Seikwan Oh, Jae-Gon Lee, Oee-Sook Park.   

Abstract

A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.

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Year:  2004        PMID： 15482917     DOI： 10.1016/j.bmcl.2004.09.009

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

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Authors:  K Mahesh Kumar; K R Roopashree; M Vinduvahini; O Kotresh; H C Devarajegowda
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7.  Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids.

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Journal:  Chem Sci       Date:  2019-07-03       Impact factor: 9.825

8.  Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.

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9.  Efficient one-pot synthesis, molecular docking and in silico ADME prediction of bis-(4-hydroxycoumarin-3-yl) methane derivatives as antileishmanial agents.

Authors:  Zahid Zaheer; Firoz A Kalam Khan; Jaiprakash N Sangshetti; Rajendra H Patil
Journal:  EXCLI J       Date:  2015-08-10       Impact factor: 4.068
  9 in total

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