Literature DB >> 15482914

Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.

Daniel P Becker1, Daniel L Flynn, Robert L Shone, Gary Gullikson.   

Abstract

Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a-d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT(4) agonist and 5-HT(3) antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

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Year:  2004        PMID： 15482914     DOI： 10.1016/j.bmcl.2004.09.005

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

2.  Azaadamantanes, a New Promising Scaffold for Medical Chemistry.

Authors:  E V Suslov; K Yu Ponomarev; K P Volcho; N F Salakhutdinov
Journal:  Russ J Bioorg Chem       Date:  2021-12-16       Impact factor: 0.796

3.  Synthesis of 2-Azaadamantan-6-one: A Missing Isomer.

Authors:  Jianbo Wu; Derek A Leas; Yuxiang Dong; Xiaofang Wang; Edward L Ezell; Douglas E Stack; Jonathan L Vennerstrom
Journal:  ACS Omega       Date:  2018-09-18

4.  ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.

Authors:  Satya Narayan; Srinivasa Ramisetti; Aruna S Jaiswal; Brian K Law; Ashona Singh-Pillay; Parvesh Singh; Shantu Amin; Arun K Sharma
Journal:  Eur J Med Chem       Date:  2018-10-23       Impact factor: 6.514
  4 in total

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