BACKGROUND: Smoking accelerates the degradation of many nutrients, including lipids, antioxidants, and certain B vitamins. Accelerated biotin catabolism is of concern in women because marginal biotin deficiency is teratogenic in mammals. OBJECTIVE: The objective was to assess the effect of smoking on the biotin status of women. DESIGN: A preliminary study of 7 women and 3 men examined the urinary concentrations of biotin and its metabolites biotin sulfoxide and bisnorbiotin in smokers. The interpretation of the results of this study was limited by the lack of a contemporaneous control group; consequently, we conducted a cohort-controlled study. Smoking women (n = 8) and nonsmoking control subjects (n = 15) provided 24-h urine samples; excretion rates of biotin, the biotin metabolites, and 3-hydroxyisovaleric acid were determined. Increased urinary excretion of 3-hydroxyisovaleric acid, which reflects a reduced activity of the biotin-dependent enzyme 3-methylcrotonyl-Co A carboxylase, is a sensitive indicator of biotin depletion at the tissue level. RESULTS: Compared with control subjects from previous studies, the smoking women in the preliminary study excreted significantly less urinary biotin (P = 0.02). Moreover, the ratio of urinary biotin sulfoxide to biotin increased (P = 0.04) in these women. In the cohort-controlled study, the urinary excretion of biotin decreased by 30% (P = 0.04), and the ratios of urinary bisnorbiotin and biotin sulfoxide to biotin increased significantly, which indicated accelerated catabolism in smokers. Moreover, the urinary excretion of 3-hydroxyisovaleric acid was greater in the smokers than in the control subjects (P = 0.04), which indicated biotin depletion in the smokers at the tissue level. CONCLUSION: These data provide evidence of accelerated biotin metabolism in smoking women, which results in marginal biotin deficiency.
BACKGROUND: Smoking accelerates the degradation of many nutrients, including lipids, antioxidants, and certain B vitamins. Accelerated biotin catabolism is of concern in women because marginal biotin deficiency is teratogenic in mammals. OBJECTIVE: The objective was to assess the effect of smoking on the biotin status of women. DESIGN: A preliminary study of 7 women and 3 men examined the urinary concentrations of biotin and its metabolites biotin sulfoxide and bisnorbiotin in smokers. The interpretation of the results of this study was limited by the lack of a contemporaneous control group; consequently, we conducted a cohort-controlled study. Smoking women (n = 8) and nonsmoking control subjects (n = 15) provided 24-h urine samples; excretion rates of biotin, the biotin metabolites, and 3-hydroxyisovaleric acid were determined. Increased urinary excretion of 3-hydroxyisovaleric acid, which reflects a reduced activity of the biotin-dependent enzyme 3-methylcrotonyl-Co A carboxylase, is a sensitive indicator of biotin depletion at the tissue level. RESULTS: Compared with control subjects from previous studies, the smoking women in the preliminary study excreted significantly less urinary biotin (P = 0.02). Moreover, the ratio of urinary biotin sulfoxide to biotin increased (P = 0.04) in these women. In the cohort-controlled study, the urinary excretion of biotin decreased by 30% (P = 0.04), and the ratios of urinary bisnorbiotin and biotin sulfoxide to biotin increased significantly, which indicated accelerated catabolism in smokers. Moreover, the urinary excretion of 3-hydroxyisovaleric acid was greater in the smokers than in the control subjects (P = 0.04), which indicated biotin depletion in the smokers at the tissue level. CONCLUSION: These data provide evidence of accelerated biotin metabolism in smoking women, which results in marginal biotin deficiency.
Authors: S Schenker; Z Q Hu; R F Johnson; Y Yang; T Frosto; B D Elliott; G I Henderson; D M Mock Journal: Alcohol Clin Exp Res Date: 1993-06 Impact factor: 3.455
Authors: Shawna L Stratton; Anna Bogusiewicz; Matthew M Mock; Nell I Mock; Amanda M Wells; Donald M Mock Journal: Am J Clin Nutr Date: 2006-08 Impact factor: 7.045
Authors: Cydne A Perry; Allyson A West; Antoinette Gayle; Lauren K Lucas; Jian Yan; Xinyin Jiang; Olga Malysheva; Marie A Caudill Journal: J Nutr Date: 2014-08-13 Impact factor: 4.798
Authors: Shawna L Stratton; Cindy L Henrich; Nell I Matthews; Anna Bogusiewicz; Amanda M Dawson; Thomas D Horvath; Suzanne N Owen; Gunnar Boysen; Jeffery H Moran; Donald M Mock Journal: J Nutr Date: 2011-12-07 Impact factor: 4.798
Authors: Shawna L Stratton; Thomas D Horvath; Anna Bogusiewicz; Nell I Matthews; Cindy L Henrich; Horace J Spencer; Jeffery H Moran; Donald M Mock Journal: J Nutr Date: 2011-01-19 Impact factor: 4.798
Authors: Shawna L Stratton; Thomas D Horvath; Anna Bogusiewicz; Nell I Matthews; Cindy L Henrich; Horace J Spencer; Jeffery H Moran; Donald M Mock Journal: Am J Clin Nutr Date: 2010-10-13 Impact factor: 7.045
Authors: Thomas D Horvath; Nell I Matthews; Shawna L Stratton; Donald M Mock; Gunnar Boysen Journal: Anal Bioanal Chem Date: 2011-09-03 Impact factor: 4.142
Authors: Danni Li; Angela Radulescu; Rupendra T Shrestha; Matthew Root; Amy B Karger; Anthony A Killeen; James S Hodges; Shu-Ling Fan; Angela Ferguson; Uttam Garg; Lori J Sokoll; Lynn A Burmeister Journal: JAMA Date: 2017-09-26 Impact factor: 56.272