Literature DB >> 1543512

Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.

H Furuta1, D F Guo, T Inagami.   

Abstract

The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library. The coding region of the human AT1 receptor gene was contained in a single exon coding segment of the gene indicating an intronless structure of the coding region. The amino acid sequence of human AT1 receptor deduced from its base sequence has 359 amino acids and showed a high degree of sequence identity to bovine and rat AT1 receptor sequences. Amino acid substitutions specific to the human AT1 receptor were mostly confined to the carboxy terminal half of the molecule. The seven-transmembrane domains are well-conserved in those sequences.

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Year:  1992        PMID： 1543512     DOI： 10.1016/0006-291x(92)91600-u

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

Review 1.  Molecular biology of angiotensin receptors and their role in human cardiovascular disease.

Authors:  V Regitz-Zagrosek; M Neuss; J Holzmeister; C Warnecke; E Fleck
Journal:  J Mol Med (Berl)       Date:  1996-05       Impact factor: 4.599

2.  Highly sensitive detection of gene expression of an intronless gene: amplification of mRNA, but not genomic DNA by nucleic acid sequence based amplification (NASBA).

Authors:  A Heim; I M Grumbach; S Zeuke; B Top
Journal:  Nucleic Acids Res       Date:  1998-05-01       Impact factor: 16.971

3.  Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors.

Authors:  P M Vanderheyden; I Verheijen; F L Fierens; J P DeBacker; G Vauquelin
Journal:  Pharm Res       Date:  2000-12       Impact factor: 4.200

4.  A computer modeling postulated mechanism for angiotensin II receptor activation.

Authors:  M P Joseph; B Maigret; J C Bonnafous; J Marie; H A Scheraga
Journal:  J Protein Chem       Date:  1995-07

5.  Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors.

Authors:  P M Vanderheyden; F L Fierens; J P De Backer; N Fraeyman; G Vauquelin
Journal:  Br J Pharmacol       Date:  1999-02       Impact factor: 8.739

6.  Spectrum of use for the angiotensin-receptor blocking drugs.

Authors:  M E Fabiani; C I Johnston
Journal:  Curr Hypertens Rep       Date:  1999-10       Impact factor: 5.369

Review 7.  Losartan potassium: a review of its pharmacology, clinical efficacy and tolerability in the management of hypertension.

Authors:  K L Goa; A J Wagstaff
Journal:  Drugs       Date:  1996-05       Impact factor: 9.546

8.  Comparative pharmacology of recombinant rat AT1A, AT1B and human AT1 receptors expressed by transfected COS-M6 cells.

Authors:  A J Balmforth; S E Bryson; A J Aylett; P Warburton; S G Ball; K T Pun; D Middlemiss; G M Drew
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

9.  Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture.

Authors:  H Matsubara; M Kanasaki; S Murasawa; Y Tsukaguchi; Y Nio; M Inada
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

10.  Human AT1 receptor is a single copy gene: characterization in a stable cell line.

Authors:  N Aiyar; E Baker; H L Wu; P Nambi; R M Edwards; J J Trill; C Ellis; D J Bergsma
Journal:  Mol Cell Biochem       Date:  1994-02-09       Impact factor: 3.396
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