| Literature DB >> 15351133 |
D C Walker1, J Southgate, G Hill, M Holcombe, D R Hose, S M Wood, S Mac Neil, R H Smallwood.
Abstract
We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models.Entities:
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Year: 2004 PMID： 15351133 DOI： 10.1016/j.biosystems.2004.05.025
Source DB: PubMed Journal: Biosystems ISSN： 0303-2647 Impact factor: 1.973