Literature DB >> 15342607

Extensive genomic polymorphism within Mycobacterium avium.

Makeda Semret1, Gary Zhai, Serge Mostowy, Cynthia Cleto, David Alexander, Gerard Cangelosi, Debby Cousins, Desmond M Collins, Dick van Soolingen, Marcel A Behr.   

Abstract

We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.

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Year:  2004        PMID： 15342607      PMCID： PMC515132          DOI： 10.1128/JB.186.18.6332-6334.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

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5.  Comparative genomics of BCG vaccines by whole-genome DNA microarray.

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Review 9.  Health impacts of environmental mycobacteria.

Authors:  Todd P Primm; Christie A Lucero; Joseph O Falkinham
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10.  Genomic deletions suggest a phylogeny for the Mycobacterium tuberculosis complex.

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  37 in total

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2.  Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

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3.  The two-component regulatory system mtrAB is required for morphotypic multidrug resistance in Mycobacterium avium.

Authors:  Gerard A Cangelosi; Julie S Do; Robert Freeman; John G Bennett; Makeda Semret; Marcel A Behr
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7.  Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.

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8.  Genomic polymorphisms for Mycobacterium avium subsp. paratuberculosis diagnostics.

Authors:  Makeda Semret; David C Alexander; Christine Y Turenne; Petra de Haas; Pieter Overduin; Dick van Soolingen; Debby Cousins; Marcel A Behr
Journal:  J Clin Microbiol       Date:  2005-08       Impact factor: 5.948

9.  Species of environmental mycobacteria differ in their abilities to grow in human, mouse, and carp macrophages and with regard to the presence of mycobacterial virulence genes, as observed by DNA microarray hybridization.

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Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191
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