Literature DB >> 15341958

Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles.

Sanath K Meegalla1, Dario Doller, DeYou Sha, Rich Soll, Nancy Wisnewski, Gary M Silver, Dale Dhanoa.   

Abstract

A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.

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Year:  2004        PMID: 15341958     DOI: 10.1016/j.bmcl.2004.07.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

1.  4-Bromo-5-[(5,5-dimethyl-4,5-dihydro-isoxazol-3-yl)sulfonyl-meth-yl]-3-methyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazole.

Authors:  Hong-Ju Ma; Qian-Fei Zhao; Xiang-Dong Mei; Jun Ning
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-10

2.  Approaches towards the synthesis of 5-aminopyrazoles.

Authors:  Ranjana Aggarwal; Vinod Kumar; Rajiv Kumar; Shiv P Singh
Journal:  Beilstein J Org Chem       Date:  2011-02-09       Impact factor: 2.883

3.  X-ray supramolecular structure, NMR spectroscopy and synthesis of 3-methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-ones formed by the unexpected cyclization of 3-[1-(phenyl-hydrazono)ethyl]-chromen-2-ones.

Authors:  Itzia I Padilla-Martinez; Irma Y Flores-Larios; Efren V García-Baez; Jorge Gonzalez; Alejandro Cruz; Francisco J Martínez-Martinez
Journal:  Molecules       Date:  2011-01-21       Impact factor: 4.411

4.  2-(1,5-Diphenyl-1H-pyrazol-3-yl-oxy)-1-(2-sulfanyl-idene-1,3-thia-zolidin-3-yl)-ethanone.

Authors:  Yi Li; Yuan-Yuan Liu; Xiao-Hui Xiong; Ping Wei
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-07-10

5.  Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A.

Authors:  Jing Tang; Jewn Giew Park; Charles B Millard; James J Schmidt; Yuan-Ping Pang
Journal:  PLoS One       Date:  2007-08-22       Impact factor: 3.240

  5 in total

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