Literature DB >> 15331691

Retroviral capsid determinants of Fv1 NB and NR tropism.

Anthony Stevens1, Michael Bock, Scott Ellis, Paul LeTissier, Kate N Bishop, Melvyn W Yap, Willie Taylor, Jonathan P Stoye.   

Abstract

The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1. Copyright 2004 American Society for Microbiology

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Year:  2004        PMID： 15331691      PMCID： PMC514981          DOI： 10.1128/JVI.78.18.9592-9598.2004

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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