Literature DB >> 15328138

Activities of dicationic compounds against Trichomonas vaginalis.

Andrea L Crowell1, Chad E Stephens, Arvind Kumar, David W Boykin, W Evan Secor.   

Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 microM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

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Year:  2004        PMID： 15328138      PMCID： PMC514753          DOI： 10.1128/AAC.48.9.3602-3605.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.

Authors:  C E Stephens; F Tanious; S Kim; W D Wilson; W A Schell; J R Perfect; S G Franzblau; D W Boykin
Journal:  J Med Chem       Date:  2001-05-24       Impact factor: 7.446

2.  In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.

Authors:  Andrea L Crowell; Kolby A Sanders-Lewis; W Evan Secor
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

3.  Trichomonal Vaginitis Resistant to Metranidazole.

Authors:  S C Robinson
Journal:  Can Med Assoc J       Date:  1962-04-07       Impact factor: 8.262

4.  Tinidazole therapy for metronidazole-resistant vaginal trichomoniasis.

Authors:  J D Sobel; P Nyirjesy; W Brown
Journal:  Clin Infect Dis       Date:  2001-09-17       Impact factor: 9.079

5.  2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents.

Authors:  I Francesconi; W D Wilson; F A Tanious; J E Hall; B C Bender; R R Tidwell; D McCurdy; D W Boykin
Journal:  J Med Chem       Date:  1999-06-17       Impact factor: 7.446

6.  Thiophene-based diamidine forms a "super" at binding minor groove agent.

Authors:  Sirish Mallena; Michael P H Lee; Christian Bailly; Stephen Neidle; Arvind Kumar; David W Boykin; W David Wilson
Journal:  J Am Chem Soc       Date:  2004-10-27       Impact factor: 15.419

7.  Synthesis and antiprotozoal activity of aza-analogues of furamidine.

Authors:  Mohamed A Ismail; Reto Brun; Judy D Easterbrook; Farial A Tanious; W David Wilson; David W Boykin
Journal:  J Med Chem       Date:  2003-10-23       Impact factor: 7.446

8.  The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.

Authors:  Chad E Stephens; Reto Brun; Manar M Salem; Karl A Werbovetz; Farial Tanious; W David Wilson; David W Boykin
Journal:  Bioorg Med Chem Lett       Date:  2003-06-16       Impact factor: 2.823

9.  In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.

Authors:  M Del Poeta; W A Schell; C C Dykstra; S K Jones; R R Tidwell; A Kumar; D W Boykin; J R Perfect
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191

10.  Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

Authors:  M Del Poeta; W A Schell; C C Dykstra; S Jones; R R Tidwell; A Czarny; M Bajic; A Kumar; D Boykin; J R Perfect
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191
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  1 in total

1.  Trichomonas vaginalis: treatment questions and challenges.

Authors:  W Evan Secor
Journal:  Expert Rev Anti Infect Ther       Date:  2012-02       Impact factor: 5.091
  1 in total

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