Literature DB >> 12781196

The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.

Chad E Stephens1, Reto Brun, Manar M Salem, Karl A Werbovetz, Farial Tanious, W David Wilson, David W Boykin.   

Abstract

The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC(50) values of less than 1 micro mol versus T. cruzi and five gave similar values versus L. donovani.

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Year:  2003        PMID： 12781196     DOI： 10.1016/s0960-894x(03)00319-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

1.  Activities of dicationic compounds against Trichomonas vaginalis.

Authors:  Andrea L Crowell; Chad E Stephens; Arvind Kumar; David W Boykin; W Evan Secor
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

2.  Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.

Authors:  Xiaohua Zhu; Qiang Liu; Sihyung Yang; Toufan Parman; Carol E Green; Jon C Mirsalis; Maria de Nazaré Correia Soeiro; Elen Mello de Souza; Cristiane França da Silva; Denise da Gama Jaen Batista; Chad E Stephens; Moloy Banerjee; Abdelbasset A Farahat; Manoj Munde; W David Wilson; David W Boykin; Michael Zhuo Wang; Karl A Werbovetz
Journal:  Antimicrob Agents Chemother       Date:  2012-04-16       Impact factor: 5.191

3.  Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of Plasmodium falciparum Late-Stage Development and Egress.

Authors:  Alok Tanala Patra; Tejashri Hingamire; Meenakshi A Belekar; Aoli Xiong; Gowtham Subramanian; Zbynek Bozdech; Peter Preiser; Dhanasekaran Shanmugam; Rajesh Chandramohanadas
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

4.  The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.

Authors:  A Daliry; M Q Pires; C F Silva; R S Pacheco; M Munde; C E Stephens; A Kumar; M A Ismail; Z Liu; A A Farahat; S Akay; P Som; Q Hu; D W Boykin; W D Wilson; S L De Castro; M N C Soeiro
Journal:  Antimicrob Agents Chemother       Date:  2011-08-01       Impact factor: 5.191

5.  Novel arylimidamides for treatment of visceral leishmaniasis.

Authors:  Michael Zhuo Wang; Xiaohua Zhu; Anuradha Srivastava; Qiang Liu; J Mark Sweat; Trupti Pandharkar; Chad E Stephens; Ed Riccio; Toufan Parman; Manoj Munde; Swati Mandal; Rentala Madhubala; Richard R Tidwell; W David Wilson; David W Boykin; James Edwin Hall; Dennis E Kyle; Karl A Werbovetz
Journal:  Antimicrob Agents Chemother       Date:  2010-04-05       Impact factor: 5.191

6.  Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.

Authors:  Lucas N Alberca; María L Sbaraglini; Darío Balcazar; Laura Fraccaroli; Carolina Carrillo; Andrea Medeiros; Diego Benitez; Marcelo Comini; Alan Talevi
Journal:  J Comput Aided Mol Des       Date:  2016-02-18       Impact factor: 3.686

7.  Structure-dependent binding of arylimidamides to the DNA minor groove.

Authors:  Yun Chai; Manoj Munde; Arvind Kumar; Leah Mickelson; Sen Lin; Nancy H Campbell; Moloy Banerjee; Senol Akay; Zongying Liu; Abdelbasset A Farahat; Raja Nhili; Sabine Depauw; Marie-Hélène David-Cordonnier; Stephen Neidle; W David Wilson; David W Boykin
Journal:  Chembiochem       Date:  2013-12-09       Impact factor: 3.164

8.  Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

Authors:  Reem K Arafa; Mohamed A Ismail; Manoj Munde; W David Wilson; Tanja Wenzler; Reto Brun; David W Boykin
Journal:  Eur J Med Chem       Date:  2008-02-29       Impact factor: 6.514

9.  Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides.

Authors:  Moloy Banerjee; Abdelbasset A Farahat; Arvind Kumar; Tanja Wenzler; Reto Brun; Manoj M Munde; W David Wilson; Xiaohua Zhu; Karl A Werbovetz; David W Boykin
Journal:  Eur J Med Chem       Date:  2012-07-14       Impact factor: 6.514

10.  Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.

Authors:  Trupti Pandharkar; Xiaohua Zhu; Radhika Mathur; Jinmai Jiang; Thomas D Schmittgen; Chandrima Shaha; Karl A Werbovetz
Journal:  Antimicrob Agents Chemother       Date:  2014-06-02       Impact factor: 5.191
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