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Literature DB >> 1531387

D1 dopamine receptor binding in mood disorders measured by positron emission tomography.

T Suhara¹, K Nakayama, O Inoue, H Fukuda, M Shimizu, A Mori, Y Tateno.

Abstract

D1 dopamine receptor binding in mood disorders was studied by positron emission tomography (PET) using 11C-SCH23390. Ten patients with bipolar mood disorders and 21 normal controls were studied in the drug-free state. The patients were in euthymic (N = 6), depressed (N = 3) and manic (N = 1) states. Regional radioactivity in the brain was followed for 40 min by PET. A two-compartment model was used to obtain the binding potential (k3/k4) for the striatum and frontal cortex. The binding potentials for the frontal cortex for the patients were significantly lower than those for normal controls, whereas those for striatum were not significantly different. These findings suggest that D1 dopamine receptors in the frontal cortex may be in a different state in patients with bipolar mood disorders.

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Year: 1992 PMID： 1531387 DOI： 10.1007/bf02253582

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

34 in total

1. Effect of desipramine on dopamine receptor binding in vivo.

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Authors: G Nowak; J Zak
Journal: Eur J Pharmacol Date: 1989-08-22 Impact factor: 4.432

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Authors: D C Chugani; R F Ackermann; M E Phelps
Journal: J Cereb Blood Flow Metab Date: 1988-06 Impact factor: 6.200

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Journal: Eur J Pharmacol Date: 1986-10-07 Impact factor: 4.432

5. Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.

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Authors: T Koyama
Journal: Hokkaido Igaku Zasshi Date: 1987-05

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Authors: P H Andersen; J A Gingrich; M D Bates; A Dearry; P Falardeau; S E Senogles; M G Caron
Journal: Trends Pharmacol Sci Date: 1990-06 Impact factor: 14.819

8. Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.

Authors: L R Baxter; M E Phelps; J C Mazziotta; J M Schwartz; R H Gerner; C E Selin; R M Sumida
Journal: Arch Gen Psychiatry Date: 1985-05

9. Possible role of dopamine D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants.

Authors: G Serra; M Collu; P S D'Aquila; G M De Montis; G L Gessa
Journal: Brain Res Date: 1990-09-17 Impact factor: 3.252

10. Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112.

Authors: Dara M Cannon; Jacqueline M Klaver; Summer A Peck; Denise Rallis-Voak; Kristine Erickson; Wayne C Drevets
Journal: Neuropsychopharmacology Date: 2008-10-22 Impact factor: 7.853

D1 dopamine receptor binding in mood disorders measured by positron emission tomography.

1. Effect of desipramine on dopamine receptor binding in vivo.

2. Repeated electroconvulsive shock (ECS) enhances striatal D-1 dopamine receptor turnover in rats.

3. In vivo [3H]spiperone binding: evidence for accumulation in corpus striatum by agonist-mediated receptor internalization.

4. The D-1 dopamine receptor antagonist SCH 23390 also interacts potently with brain serotonin (5-HT2) receptors.

5. Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.

6. [The effect of lithium treatment on the activity of central dopaminergic neurons].

Review 7. Dopamine receptor subtypes: beyond the D1/D2 classification.

8. Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.

9. Possible role of dopamine D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants.

10. Chronic imipramine reduces [3H]SCH 23390 binding and DA-sensitive adenylate cyclase in the limbic system.

1. Chronic fluoxetine selectively upregulates dopamine D₁-like receptors in the hippocampus.

Review 2. Positron emission tomography molecular imaging in late-life depression.

3. Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis.

4. Dysregulation of Striatal Dopamine Receptor Binding in Suicide.

Review 5. The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited.

Review 6. Molecular imaging in patients with mood disorders: a review of PET findings.

7. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine.

8. Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients.

9. Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.

10. Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112.