Literature DB >> 3536532

The D-1 dopamine receptor antagonist SCH 23390 also interacts potently with brain serotonin (5-HT2) receptors.

S Bischoff, M Heinrich, J M Sonntag, J Krauss.   

Abstract

The interaction of SCH 23390 with central serotonin 5-HT2 receptors was studied in vivo on [3H]spiperone binding and in vitro on [3H]ketanserin binding. SCH 23390 inhibited [3H]spiperone binding in rat frontal cortex with an ID50 of 1.5 mg/kg i.p., thus being equipotent to the two 5-HT2 antagonists cinanserin and methysergide. In vitro, SCH 23390 competed with [3H]ketanserin with an IC50 of 30 nM. These data indicate that SCH 23390 also binds with high affinity to 5-HT2 receptors in rat brain.

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Year:  1986        PMID： 3536532     DOI： 10.1016/0014-2999(86)90449-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  46 in total

1.  Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine.

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2.  The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility.

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3.  Reinstatement of cocaine seeking in rats by the pharmacological stressors, corticotropin-releasing factor and yohimbine: role for D1/5 dopamine receptors.

Authors:  Z J Brown; D A Kupferschmidt; Suzanne Erb
Journal:  Psychopharmacology (Berl)       Date:  2012-06-17       Impact factor: 4.530

4.  Age-related changes in human D1 dopamine receptors measured by positron emission tomography.

Authors:  T Suhara; H Fukuda; O Inoue; T Itoh; K Suzuki; T Yamasaki; Y Tateno
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

Review 5.  Drugs of abuse and immediate-early genes in the forebrain.

Authors:  R E Harlan; M M Garcia
Journal:  Mol Neurobiol       Date:  1998-06       Impact factor: 5.590

6.  Differential tolerance to cataleptic effects of SCH 23390 and haloperidol after repeated administration.

Authors:  J Lappalainen; J Hietala; E Syvälahti
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D₃-5-HT₂A and D₁-NMDA receptors in the mPFC.

Authors:  Hirotake Hida; Akihiro Mouri; Kentaro Mori; Yurie Matsumoto; Takeshi Seki; Masayuki Taniguchi; Kiyofumi Yamada; Kunihiro Iwamoto; Norio Ozaki; Toshitaka Nabeshima; Yukihiro Noda
Journal:  Neuropsychopharmacology       Date:  2014-08-14       Impact factor: 7.853

8.  Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection.

Authors:  S B Floresco; C D Blaha; C R Yang; A G Phillips
Journal:  J Neurosci       Date:  2001-04-15       Impact factor: 6.167

9.  Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory.

Authors:  Joshua Sariñana; Takashi Kitamura; Patrik Künzler; Lisa Sultzman; Susumu Tonegawa
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-19       Impact factor: 11.205

10.  Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.

Authors:  D S Reynolds; R J Carter; A J Morton
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167
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