BACKGROUND: There is increasing interest in the predictive value of C-reactive protein (CRP) and fibrin D-dimer in the prediction of ischemic heart disease (IHD). We assessed their joint and independent associations with IHD in a large combined analysis of 2 population cohorts. METHODS AND RESULTS: Men aged 49 to 66 years from the general populations of Caerphilly and Speedwell were studied between 1982 and 1988 and re-examined for new IHD events at fixed intervals of approximately 105 months (Caerphilly) and 75 months (Speedwell). 3213 men had CRP and D-dimer measured at baseline and 351 (11%) had a new IHD event. Mean levels of CRP and D-dimer were significantly higher among men in whom IHD developed. The relative odds of IHD in men in the top 20% of the distribution of CRP was 2.97 (95% CI, 2.04, 4.32) and for D-dimer was 2.40 (95% CI, 1.69, 3.40); CRP and D-dimer had additive effects on risk of IHD. Multivariate analysis reduced the size of the relative odds, which remained significant for D-dimer. CONCLUSIONS: Both inflammatory and thrombogenic markers are important (and potentially additive) predictors of coronary risk.
BACKGROUND: There is increasing interest in the predictive value of C-reactive protein (CRP) and fibrin D-dimer in the prediction of ischemic heart disease (IHD). We assessed their joint and independent associations with IHD in a large combined analysis of 2 population cohorts. METHODS AND RESULTS:Men aged 49 to 66 years from the general populations of Caerphilly and Speedwell were studied between 1982 and 1988 and re-examined for new IHD events at fixed intervals of approximately 105 months (Caerphilly) and 75 months (Speedwell). 3213 men had CRP and D-dimer measured at baseline and 351 (11%) had a new IHD event. Mean levels of CRP and D-dimer were significantly higher among men in whom IHD developed. The relative odds of IHD in men in the top 20% of the distribution of CRP was 2.97 (95% CI, 2.04, 4.32) and for D-dimer was 2.40 (95% CI, 1.69, 3.40); CRP and D-dimer had additive effects on risk of IHD. Multivariate analysis reduced the size of the relative odds, which remained significant for D-dimer. CONCLUSIONS: Both inflammatory and thrombogenic markers are important (and potentially additive) predictors of coronary risk.
Authors: Kiran Musunuru; Brian G Kral; Roger S Blumenthal; Valentin Fuster; Catherine Y Campbell; Ty J Gluckman; Richard A Lange; Eric J Topol; James T Willerson; Milind Y Desai; Michael H Davidson; Samia Mora Journal: Nat Clin Pract Cardiovasc Med Date: 2008-08-19
Authors: Lu-Chen Weng; Weihong Tang; Stephen S Rich; Nicholas L Smith; Susan Redline; Christopher J O'Donnell; Saonli Basu; Alexander P Reiner; Joseph A Delaney; Russell P Tracy; Cameron D Palmer; Taylor Young; Qiong Yang; Aaron R Folsom; Mary Cushman Journal: Thromb Res Date: 2014-05-20 Impact factor: 3.944
Authors: Frank J Palella; Stephen J Gange; Lorie Benning; Lisa Jacobson; Robert C Kaplan; Alan L Landay; Russell P Tracy; Richard Elion Journal: AIDS Date: 2010-07-17 Impact factor: 4.177
Authors: Meghan M Holst; Michael D Wirth; Anna Mnatsakanova; James B Burch; Luenda E Charles; Cathy Tinney-Zara; Desta Fekedulegn; Michael E Andrew; Tara A Hartley; John M Violanti Journal: J Occup Environ Med Date: 2019-05 Impact factor: 2.162
Authors: Charles X Kim; Kent R Bailey; George G Klee; Allison A Ellington; Guanghui Liu; Thomas H Mosley; Hamid Rehman; Iftikhar J Kullo Journal: PLoS One Date: 2010-02-05 Impact factor: 3.240
Authors: Andrew W Fogarty; Sarah A Lewis; Tricia M McKeever; Gordon D O Lowe; Lorna Clark; John Britton Journal: PLoS One Date: 2010-11-16 Impact factor: 3.240
Authors: Paul Elliott; John C Chambers; Weihua Zhang; Robert Clarke; Jemma C Hopewell; John F Peden; Jeanette Erdmann; Peter Braund; James C Engert; Derrick Bennett; Lachlan Coin; Deborah Ashby; Ioanna Tzoulaki; Ian J Brown; Shahrul Mt-Isa; Mark I McCarthy; Leena Peltonen; Nelson B Freimer; Martin Farrall; Aimo Ruokonen; Anders Hamsten; Noha Lim; Philippe Froguel; Dawn M Waterworth; Peter Vollenweider; Gerard Waeber; Marjo-Riitta Jarvelin; Vincent Mooser; James Scott; Alistair S Hall; Heribert Schunkert; Sonia S Anand; Rory Collins; Nilesh J Samani; Hugh Watkins; Jaspal S Kooner Journal: JAMA Date: 2009-07-01 Impact factor: 56.272
Authors: Bernard Panaszek; Ewa Liebhart; Jerzy Liebhart; Robert Pawłowicz; Andrzej M Fal Journal: Arch Immunol Ther Exp (Warsz) Date: 2007 Sep-Oct Impact factor: 4.291