| Literature DB >> 33980977 |
Xingjin Yang1, Dongdong Zhang2, Yang Zhao1, Dechen Liu1,3, Quanman Li1, Chunmei Guo1, Gang Tian1, Minghui Han1, Ranran Qie1, Shengbing Huang1, Qionggui Zhou3, Yang Zhao1, Yifei Feng1, Xiaoyan Wu3, Yanyan Zhang3, Yang Li3, Yuying Wu3, Cheng Cheng1, Dongsheng Hu4, Liang Sun5.
Abstract
Although the association between serum level of C-reactive protein (CRP) and risk of cardiovascular events (CVEs) has been reported, the comprehensive assessment of the quantitative association of CRP level with risk of CVEs has not been reported. Our meta-analysis aims to quantitatively evaluate the association of CRP level and risk of CVEs. We searched PubMed and Embase databases for articles published up to December 6, 2019. Studies with data on men and women, different types of CVEs and multiple cohorts within a study were treated as independent studies. Generalized least-squares regression models were used to assess the quantitative association between CRP level and risk of CVEs. Restricted cubic splines were used to model the possible linear association between CRP and CVEs. We included 36 articles (60 studies; 227,715 participants) in the analysis. The pooled relative risks (RRs) of high versus low CRP level for cardiovascular disease (CVD), stroke and coronary heart disease (CHD) were 1.64 (95% confidence interval [CI], 1.49-1.82), 1.46 (95% CI, 1.35-1.58), and 1.55 (95% CI, 1.47-1.63), respectively. A linear association was found between CRP level and CVD (P = 0.429), stroke (P = 0.940), and CHD (P = 0.931); with each 1-mg/L increase in CRP level, the pooled RRs for CVD, stroke, and CHD were 1.18 (95% CI, 1.12-1.24), 1.07 (95% CI, 1.04-1.09), and 1.12 (95% CI, 1.08-1.16), respectively. This meta-analysis suggests that risk of CVEs increases with increasing serum CRP level.Entities:
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Year: 2021 PMID： 33980977 DOI： 10.1038/s41371-021-00546-z
Source DB: PubMed Journal: J Hum Hypertens ISSN： 0950-9240 Impact factor: 3.012