Meghan M Holst1, Michael D Wirth, Anna Mnatsakanova, James B Burch, Luenda E Charles, Cathy Tinney-Zara, Desta Fekedulegn, Michael E Andrew, Tara A Hartley, John M Violanti. 1. Department of Epidemiology and Biostatistics, Arnold School of Public Health (Mr Holst, Dr Wirth, Dr Burch); Cancer Prevention and Control Program (Dr Wirth, Dr Burch); College of Nursing (Dr Wirth), University of South Carolina; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Ms Mnatsakanova, Dr Charles, Ms Tinney-Zara, Dr Fekedulegn, Dr Andrew, Dr Hartley); WJB Dorn VA Medical Center (Dr Burch), Columbia, South Carolina; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University of Buffalo, The State University of New York, Buffalo, New York (Dr Violanti).
Abstract
OBJECTIVE: To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort. METHODS: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. RESULTS: Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m versus the day shift. CONCLUSIONS: Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.
OBJECTIVE: To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort. METHODS: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. RESULTS: Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m versus the day shift. CONCLUSIONS: Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.
Authors: L Di Lorenzo; G De Pergola; C Zocchetti; N L'Abbate; A Basso; N Pannacciulli; M Cignarelli; R Giorgino; L Soleo Journal: Int J Obes Relat Metab Disord Date: 2003-11
Authors: Thomas A Pearson; George A Mensah; R Wayne Alexander; Jeffrey L Anderson; Richard O Cannon; Michael Criqui; Yazid Y Fadl; Stephen P Fortmann; Yuling Hong; Gary L Myers; Nader Rifai; Sidney C Smith; Kathryn Taubert; Russell P Tracy; Frank Vinicor Journal: Circulation Date: 2003-01-28 Impact factor: 29.690