Literature DB >> 15288263

Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.

Karine Lefort1, G Paolo Dotto.   

Abstract

Oncogenesis is closely linked to abnormalities in cell differentiation. Notch signaling provides an important form of intercellular communication involved in cell fate determination, stem cell potential and differentiation. Here we review the role of this pathway in the integrated growth/differentiation control of the keratinocyte cell type, and the maintenance of normal skin homeostasis. In parallel with the pro-differentiation function of Notch1 in keratinocytes, we discuss recent evidence pointing to a tumor suppressor function of this gene in both mouse skin and human cervical carcinogenesis. The possibility that Notch signaling elicits signals with a duality of growth positive and negative function will be discussed.

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Year:  2004        PMID： 15288263     DOI： 10.1016/j.semcancer.2004.04.017

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  47 in total

Review 1.  Notch signaling in hematopoietic stem cells.

Authors:  Takahiro Suzuki; Shigeru Chiba
Journal:  Int J Hematol       Date:  2005-11       Impact factor: 2.490

2.  p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.

Authors:  Vikram Devgan; Cristina Mammucari; Sarah E Millar; Cathrin Brisken; G Paolo Dotto
Journal:  Genes Dev       Date:  2005-06-15       Impact factor: 11.361

3.  Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells.

Authors:  Katherine C Jordan; Valerie Schaeffer; Karin A Fischer; Elizabeth E Gray; Hannele Ruohola-Baker
Journal:  BMC Dev Biol       Date:  2006-03-16       Impact factor: 1.978

4.  Activated Notch1 maintains the phenotype of radial glial cells and promotes their adhesion to laminin by upregulating nidogen.

Authors:  Hedong Li; Yu-Wen Chang; Kriti Mohan; Hui-Wen Su; Christopher L Ricupero; Ajoeb Baridi; Ronald P Hart; Martin Grumet
Journal:  Glia       Date:  2008-04-15       Impact factor: 7.452

Review 5.  Drosophila follicle cells: morphogenesis in an eggshell.

Authors:  Xiaodong Wu; Pradeep Singh Tanwar; Laurel A Raftery
Journal:  Semin Cell Dev Biol       Date:  2008-01-20       Impact factor: 7.727

6.  Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.

Authors:  V Rocher-Ros; S Marco; J-H Mao; S Gines; D Metzger; P Chambon; A Balmain; C A Saura
Journal:  Oncogene       Date:  2010-03-08       Impact factor: 9.867

7.  The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo.

Authors:  Peng Xu; Mingzhe Qiu; Zhiyong Zhang; Chunsheng Kang; Rongcai Jiang; Zhifan Jia; Guangxiu Wang; Hao Jiang; Peiyu Pu
Journal:  J Neurooncol       Date:  2009-09-22       Impact factor: 4.130

Review 8.  Crosstalk of Notch with p53 and p63 in cancer growth control.

Authors:  G Paolo Dotto
Journal:  Nat Rev Cancer       Date:  2009-07-16       Impact factor: 60.716

9.  Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch.

Authors:  Aadithya Arumugam; Zhiping Weng; Sandeep C Chaudhary; Farrukh Afaq; Craig A Elmets; Mohammad Athar
Journal:  Biochem Biophys Res Commun       Date:  2014-08-02       Impact factor: 3.575

10.  Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes.

Authors:  Jennifer M Taylor; Teresa L Street; Lizhong Hao; Richard Copley; Martin S Taylor; Patrick J Hayden; Gina Stolper; Richard Mott; Jotun Hein; Miriam F Moffatt; William O C M Cookson
Journal:  PLoS One       Date:  2009-10-30       Impact factor: 3.240
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