Literature DB >> 19609265

Crosstalk of Notch with p53 and p63 in cancer growth control.

G Paolo Dotto1.   

Abstract

Understanding the complexity of cancer depends on an elucidation of the underlying regulatory networks, at the cellular and intercellular levels and in their temporal dimension. This Opinion article focuses on the multilevel crosstalk between the Notch pathway and the p53 and p63 pathways. These two coordinated signalling modules are at the interface of external damaging signals and control of stem cell potential and differentiation. Positive or negative reciprocal regulation of the two pathways can vary with cell type and cancer stage. Therefore, selective or combined targeting of the two pathways could improve the efficacy and reduce the toxicity of cancer therapies.

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Year:  2009        PMID： 19609265      PMCID： PMC6059364          DOI： 10.1038/nrc2675

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  157 in total

1.  Off the beaten pathway: the complex cross talk between Notch and NF-kappaB.

Authors:  Clodia Osipo; Todd E Golde; Barbara A Osborne; Lucio A Miele
Journal:  Lab Invest       Date:  2007-12-03       Impact factor: 5.662

2.  The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions.

Authors:  B Daniel; A Rangarajan; G Mukherjee; E Vallikad; S Krishna
Journal:  J Gen Virol       Date:  1997-05       Impact factor: 3.891

3.  The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells.

Authors:  Ryan T Phan; Riccardo Dalla-Favera
Journal:  Nature       Date:  2004-12-02       Impact factor: 49.962

4.  Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.

Authors:  Claudio Talora; Dennis C Sgroi; Christopher P Crum; G Paolo Dotto
Journal:  Genes Dev       Date:  2002-09-01       Impact factor: 11.361

5.  Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Authors:  Yunsun Nam; Piotr Sliz; Luyan Song; Jon C Aster; Stephen C Blacklow
Journal:  Cell       Date:  2006-03-10       Impact factor: 41.582

6.  EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

Authors:  Vihren Kolev; Anna Mandinova; Juan Guinea-Viniegra; Bing Hu; Karine Lefort; Chiara Lambertini; Victor Neel; Reinhard Dummer; Erwin F Wagner; G Paolo Dotto
Journal:  Nat Cell Biol       Date:  2008-07-06       Impact factor: 28.824

Review 7.  Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.

Authors:  Karine Lefort; G Paolo Dotto
Journal:  Semin Cancer Biol       Date:  2004-10       Impact factor: 15.707

Review 8.  Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.

Authors:  A S McElhinny; J-L Li; L Wu
Journal:  Oncogene       Date:  2008-09-01       Impact factor: 9.867

9.  Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

Authors:  J P Roperch; V Alvaro; S Prieur; M Tuynder; M Nemani; F Lethrosne; L Piouffre; M C Gendron; D Israeli; J Dausset; M Oren; R Amson; A Telerman
Journal:  Nat Med       Date:  1998-07       Impact factor: 53.440

10.  Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.

Authors:  Karine Lefort; Anna Mandinova; Paola Ostano; Vihren Kolev; Valerie Calpini; Ingrid Kolfschoten; Vikram Devgan; Jocelyn Lieb; Wassim Raffoul; Daniel Hohl; Victor Neel; Jonathan Garlick; Giovanna Chiorino; G Paolo Dotto
Journal:  Genes Dev       Date:  2007-03-01       Impact factor: 11.361
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  92 in total

Review 1.  [Malignancy potential of precursor lesions: determination using molecular markers].

Authors:  A Jung
Journal:  Pathologe       Date:  2011-11       Impact factor: 1.011

2.  ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.

Authors:  Rose-Anne Romano; Kirsten Smalley; Caitlin Magraw; Vanida Ann Serna; Takeshi Kurita; Srikala Raghavan; Satrajit Sinha
Journal:  Development       Date:  2012-02       Impact factor: 6.868

3.  Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.

Authors:  Juan Guinea-Viniegra; Rainer Zenz; Harald Scheuch; María Jiménez; Latifa Bakiri; Peter Petzelbauer; Erwin F Wagner
Journal:  J Clin Invest       Date:  2012-07-09       Impact factor: 14.808

Review 4.  The p53 orchestra: Mdm2 and Mdmx set the tone.

Authors:  Mark Wade; Yunyuan V Wang; Geoffrey M Wahl
Journal:  Trends Cell Biol       Date:  2010-02-19       Impact factor: 20.808

5.  Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.

Authors:  Takashi Yugawa; Koichiro Nishino; Shin-Ichi Ohno; Tomomi Nakahara; Masatoshi Fujita; Naoki Goshima; Akihiro Umezawa; Tohru Kiyono
Journal:  Mol Cell Biol       Date:  2013-09-09       Impact factor: 4.272

Review 6.  Notch as a tumour suppressor.

Authors:  Craig S Nowell; Freddy Radtke
Journal:  Nat Rev Cancer       Date:  2017-02-03       Impact factor: 60.716

Review 7.  Immune system modulation of kidney regeneration--mechanisms and implications.

Authors:  Hans-Joachim Anders
Journal:  Nat Rev Nephrol       Date:  2014-04-29       Impact factor: 28.314

Review 8.  Stacking the DEK: from chromatin topology to cancer stem cells.

Authors:  Lisa M Privette Vinnedge; Ferdinand Kappes; Nicolas Nassar; Susanne I Wells
Journal:  Cell Cycle       Date:  2012-12-19       Impact factor: 4.534

Review 9.  Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives.

Authors:  Simonetta Ausoni; Paolo Boscolo-Rizzo; Bhuvanesh Singh; Maria Cristina Da Mosto; Giacomo Spinato; Giancarlo Tirelli; Roberto Spinato; Giuseppe Azzarello
Journal:  Cancer Metastasis Rev       Date:  2016-09       Impact factor: 9.264

10.  Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.

Authors:  Curtis R Pickering; Jiexin Zhang; Suk Young Yoo; Linnea Bengtsson; Shhyam Moorthy; David M Neskey; Mei Zhao; Marcus V Ortega Alves; Kyle Chang; Jennifer Drummond; Elsa Cortez; Tong-Xin Xie; Di Zhang; Woonbok Chung; Jean-Pierre J Issa; Patrick A Zweidler-McKay; Xifeng Wu; Adel K El-Naggar; John N Weinstein; Jing Wang; Donna M Muzny; Richard A Gibbs; David A Wheeler; Jeffrey N Myers; Mitchell J Frederick
Journal:  Cancer Discov       Date:  2013-04-25       Impact factor: 39.397
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